Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1164214..1164863 Replicon chromosome
Accession NZ_CP104014
Organism Enterobacter sp. CP102

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N1249_RS05450 Protein ID WP_259835152.1
Coordinates 1164501..1164863 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N1249_RS05445 Protein ID WP_259835150.1
Coordinates 1164214..1164513 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1249_RS05430 (N1249_05430) 1159250..1160332 + 1083 WP_259835144.1 SMP-30/gluconolactonase/LRE family protein -
N1249_RS05435 (N1249_05435) 1160386..1162572 + 2187 WP_259835146.1 TonB-dependent siderophore receptor -
N1249_RS05440 (N1249_05440) 1162675..1164063 + 1389 WP_259835148.1 phenylalanine transporter -
N1249_RS05445 (N1249_05445) 1164214..1164513 - 300 WP_259835150.1 helix-turn-helix transcriptional regulator Antitoxin
N1249_RS05450 (N1249_05450) 1164501..1164863 - 363 WP_259835152.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N1249_RS05455 (N1249_05455) 1165070..1166308 + 1239 WP_259835154.1 MFS transporter -
N1249_RS05460 (N1249_05460) 1166324..1167349 + 1026 WP_259835163.1 sugar phosphate isomerase/epimerase -
N1249_RS05465 (N1249_05465) 1167342..1168484 + 1143 WP_259835165.1 Gfo/Idh/MocA family oxidoreductase -
N1249_RS05470 (N1249_05470) 1168560..1169531 + 972 WP_259835167.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13908.98 Da        Isoelectric Point: 7.3223

>T257002 WP_259835152.1 NZ_CP104014:c1164863-1164501 [Enterobacter sp. CP102]
MWDIETTDRFDKWFFNQTLALKEDVLAAMHILAEFGPQLGRPYVDTVKASAYPNMKELRIQHSGDPIRAFFAFDPRRTAI
VLCAGDKSGCVEKRFYNEMIKLADAEFSKHLANKEAIWHR

Download         Length: 363 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10878.63 Da        Isoelectric Point: 10.2013

>AT257002 WP_259835150.1 NZ_CP104014:c1164513-1164214 [Enterobacter sp. CP102]
MASLKELMAQQSAESQERIATKVEKMRRIVALNQLREELSVSQTELAAAMGVKQPTVAKIEQPGNDPRLSTLKRYVSALG
GELSIDVTLPNGKRIAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References