Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 56572..57280 Replicon chromosome
Accession NZ_CP104006
Organism Yersinia alsatica strain SCPM-O-B-7604

Toxin (Protein)


Gene name higB Uniprot ID A0A0T9UP84
Locus tag N0H69_RS00250 Protein ID WP_050109236.1
Coordinates 56960..57280 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N0H69_RS00245 Protein ID WP_050109237.1
Coordinates 56572..56910 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0H69_RS00215 (N0H69_00215) 51664..52020 + 357 WP_050109241.1 YibL family ribosome-associated protein -
N0H69_RS00220 (N0H69_00220) 52086..52409 - 324 WP_253272122.1 type II toxin-antitoxin system YafQ family toxin -
N0H69_RS00225 (N0H69_00225) 52387..52668 - 282 WP_050123827.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
N0H69_RS00230 (N0H69_00230) 52753..53445 - 693 WP_050151868.1 6-hydroxyaminopurine reductase -
N0H69_RS00235 (N0H69_00235) 53524..55482 - 1959 WP_050151870.1 methyl-accepting chemotaxis protein -
N0H69_RS00240 (N0H69_00240) 55770..56393 - 624 WP_050099416.1 superoxide dismutase [Mn] -
N0H69_RS00245 (N0H69_00245) 56572..56910 - 339 WP_050109237.1 HigA family addiction module antitoxin Antitoxin
N0H69_RS00250 (N0H69_00250) 56960..57280 - 321 WP_050109236.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0H69_RS00255 (N0H69_00255) 57356..58207 - 852 WP_172665459.1 formate dehydrogenase accessory sulfurtransferase FdhD -
N0H69_RS00260 (N0H69_00260) 58516..61563 + 3048 WP_151420028.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(11-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-69)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12397.08 Da        Isoelectric Point: 10.1709

>T256979 WP_050109236.1 NZ_CP104006:c57280-56960 [Yersinia alsatica]
MDKHKKRSIGSFRDTWLEGFFEHGGRHRKIPASIENVLARKLDIINAAISYKDLRSPPANRYEELNPPLEGYSSIRINDQ
YRLIFVWANGKANDLYLDAHGYKKHR

Download         Length: 321 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.91 Da        Isoelectric Point: 5.8990

>AT256979 WP_050109237.1 NZ_CP104006:c56910-56572 [Yersinia alsatica]
MVQAQRKPTSVGDVLLYEYIEPTGIKINDLAEMLQVHRNTISALVNNNRKLTTDMAFRLAKAFDTSEEFWINLQANVDIW
EVQNDNRIQEELSRVITLDDFLKRKEKSKKLA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9UP84

Antitoxin

Source ID Structure

References