Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 56572..57280 Replicon chromosome
Accession NZ_CP104006
Organism Yersinia alsatica strain SCPM-O-B-7604

Toxin (Protein)


Gene name higB Uniprot ID A0A0T9UP84
Locus tag N0H69_RS00250 Protein ID WP_050109236.1
Coordinates 56960..57280 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N0H69_RS00245 Protein ID WP_050109237.1
Coordinates 56572..56910 (-) Length 113 a.a.

Genomic Context

N0H69_RS00215N0H69_RS00260N0H69_RS00220N0H69_RS00225N0H69_RS00230N0H69_RS00235N0H69_RS00240N0H69_RS00245N0H69_RS00250N0H69_RS00255
Location: 51664..52020 (357 bp)
Type: Others
Protein ID: WP_050109241.1
Location: 58516..61563 (3048 bp)
Type: Others
Protein ID: WP_151420028.1
Location: 52086..52409 (324 bp)
Type: Others
Protein ID: WP_253272122.1
Location: 52387..52668 (282 bp)
Type: Others
Protein ID: WP_050123827.1
Location: 52753..53445 (693 bp)
Type: Others
Protein ID: WP_050151868.1
Location: 53524..55482 (1959 bp)
Type: Others
Protein ID: WP_050151870.1
Location: 55770..56393 (624 bp)
Type: Others
Protein ID: WP_050099416.1
Location: 56572..56910 (339 bp)
Type: Antitoxin
Protein ID: WP_050109237.1
Location: 56960..57280 (321 bp)
Type: Toxin
Protein ID: WP_050109236.1
Location: 57356..58207 (852 bp)
Type: Others
Protein ID: WP_172665459.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N0H69_RS00215 (N0H69_00215)51664..52020+357WP_050109241.1YibL family ribosome-associated protein-
N0H69_RS00220 (N0H69_00220)52086..52409-324WP_253272122.1type II toxin-antitoxin system YafQ family toxin-
N0H69_RS00225 (N0H69_00225)52387..52668-282WP_050123827.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
N0H69_RS00230 (N0H69_00230)52753..53445-693WP_050151868.16-hydroxyaminopurine reductase-
N0H69_RS00235 (N0H69_00235)53524..55482-1959WP_050151870.1methyl-accepting chemotaxis protein-
N0H69_RS00240 (N0H69_00240)55770..56393-624WP_050099416.1superoxide dismutase [Mn]-
N0H69_RS00245 (N0H69_00245)56572..56910-339WP_050109237.1HigA family addiction module antitoxinAntitoxin
N0H69_RS00250 (N0H69_00250)56960..57280-321WP_050109236.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N0H69_RS00255 (N0H69_00255)57356..58207-852WP_172665459.1formate dehydrogenase accessory sulfurtransferase FdhD-
N0H69_RS00260 (N0H69_00260)58516..61563+3048WP_151420028.1formate dehydrogenase-N subunit alpha-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(11-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-69)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12397.08 Da        Isoelectric Point: 10.1709

>T256979 WP_050109236.1 NZ_CP104006:c57280-56960 [Yersinia alsatica]
MDKHKKRSIGSFRDTWLEGFFEHGGRHRKIPASIENVLARKLDIINAAISYKDLRSPPANRYEELNPPLEGYSSIRINDQ
YRLIFVWANGKANDLYLDAHGYKKHR

Download         Length: 321 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.91 Da        Isoelectric Point: 5.8990

>AT256979 WP_050109237.1 NZ_CP104006:c56910-56572 [Yersinia alsatica]
MVQAQRKPTSVGDVLLYEYIEPTGIKINDLAEMLQVHRNTISALVNNNRKLTTDMAFRLAKAFDTSEEFWINLQANVDIW
EVQNDNRIQEELSRVITLDDFLKRKEKSKKLA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0T9UP84

Antitoxin

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Source
ID
Structure
No matching records found

References