256951

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3895189..3895730 Replicon chromosome
Accession NZ_CP103974
Organism Escherichia coli strain DLI.6n

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag NZ657_RS19070 Protein ID WP_000615983.1
Coordinates 3895452..3895730 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag NZ657_RS19065 Protein ID WP_000729703.1
Coordinates 3895189..3895449 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZ657_RS19045 (3890864) 3890864..3891649 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
NZ657_RS19050 (3891621) 3891621..3893333 + 1713 Protein_3727 flagellar biosynthesis protein FlhA -
NZ657_RS19055 (3893557) 3893557..3894054 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
NZ657_RS19060 (3894230) 3894230..3894979 - 750 WP_000056849.1 C40 family peptidase -
NZ657_RS19065 (3895189) 3895189..3895449 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NZ657_RS19070 (3895452) 3895452..3895730 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NZ657_RS19075 (3895886) 3895886..3896626 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NZ657_RS19080 (3896597) 3896597..3897364 - 768 WP_000333380.1 class II glutamine amidotransferase -
NZ657_RS19085 (3897570) 3897570..3898148 - 579 WP_077487565.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T256951 WP_000615983.1 NZ_CP103974:3895452-3895730 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT256951 WP_000729703.1 NZ_CP103974:3895189-3895449 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
AlphaFold DB A0A5F1F716

References