256941

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1918686..1919188 Replicon chromosome
Accession NZ_CP103974
Organism Escherichia coli strain DLI.6n

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NZ657_RS09115 Protein ID WP_000767829.1
Coordinates 1918934..1919188 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NZ657_RS09110 Protein ID WP_001259255.1
Coordinates 1918686..1918937 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZ657_RS09085 (1913864) 1913864..1914931 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NZ657_RS09090 (1914931) 1914931..1916001 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
NZ657_RS09095 (1915998) 1915998..1917302 - 1305 WP_000009594.1 histidinol dehydrogenase -
NZ657_RS09100 (1917308) 1917308..1918207 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NZ657_RS09105 (1918353) 1918353..1918403 - 51 WP_001364200.1 his operon leader peptide -
NZ657_RS09110 (1918686) 1918686..1918937 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NZ657_RS09115 (1918934) 1918934..1919188 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NZ657_RS09120 (1919271) 1919271..1920095 + 825 WP_000754737.1 SDR family oxidoreductase -
NZ657_RS09125 (1920141) 1920141..1921070 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NZ657_RS09130 (1921285) 1921285..1921347 + 63 WP_010723108.1 membrane protein YoeI -
NZ657_RS09135 (1921337) 1921337..1922695 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NZ657_RS09140 (1922874) 1922874..1923932 + 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
NZ657_RS09145 (1923946) 1923946..1924173 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T256941 WP_000767829.1 NZ_CP103974:1918934-1919188 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT256941 WP_001259255.1 NZ_CP103974:1918686-1918937 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References