Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2058946..2059673 Replicon chromosome
Accession NZ_CP103972
Organism Escherichia coli strain DLI.5a

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NZD79_RS10045 Protein ID WP_097342105.1
Coordinates 2059359..2059673 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NZD79_RS10040 Protein ID WP_000560266.1
Coordinates 2058946..2059362 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZD79_RS10030 (2054106) 2054106..2056457 + 2352 WP_000695487.1 alpha-glucosidase -
NZD79_RS10035 (2056883) 2056883..2058901 + 2019 WP_000121433.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
NZD79_RS10040 (2058946) 2058946..2059362 - 417 WP_000560266.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
NZD79_RS10045 (2059359) 2059359..2059673 - 315 WP_097342105.1 type II toxin-antitoxin system toxin HigB Toxin
NZD79_RS10050 (2059957) 2059957..2061093 - 1137 WP_000018695.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
NZD79_RS10055 (2061178) 2061178..2061681 + 504 WP_001333820.1 M48 family metallopeptidase -
NZD79_RS10060 (2061758) 2061758..2062450 + 693 WP_000942548.1 vancomycin high temperature exclusion protein -
NZD79_RS10065 (2062529) 2062529..2063515 + 987 WP_000617698.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12089.08 Da        Isoelectric Point: 10.0409

>T256929 WP_097342105.1 NZ_CP103972:c2059673-2059359 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESVKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14995.42 Da        Isoelectric Point: 4.4547

>AT256929 WP_000560266.1 NZ_CP103972:c2059362-2058946 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References