Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1994405..1995098 Replicon chromosome
Accession NZ_CP103972
Organism Escherichia coli strain DLI.5a

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NZD79_RS09740 Protein ID WP_000415584.1
Coordinates 1994802..1995098 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NZD79_RS09735 Protein ID WP_000650107.1
Coordinates 1994405..1994800 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZD79_RS09725 (1990269) 1990269..1992527 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
NZD79_RS09730 (1992665) 1992665..1994272 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NZD79_RS09735 (1994405) 1994405..1994800 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NZD79_RS09740 (1994802) 1994802..1995098 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NZD79_RS09745 (1995303) 1995303..1995785 - 483 WP_000183505.1 GyrI-like domain-containing protein -
NZD79_RS09750 (1995838) 1995838..1996230 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NZD79_RS09755 (1996382) 1996382..1997041 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
NZD79_RS09760 (1997038) 1997038..1998387 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
NZD79_RS09765 (1998433) 1998433..1998765 - 333 WP_000917685.1 DUF2645 family protein -
NZD79_RS09770 (1999084) 1999084..1999665 + 582 WP_259568214.1 NADPH:quinone oxidoreductase MdaB -
NZD79_RS09775 (1999696) 1999696..2000010 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T256928 WP_000415584.1 NZ_CP103972:c1995098-1994802 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT256928 WP_000650107.1 NZ_CP103972:c1994800-1994405 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References