Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 831065..831567 Replicon chromosome
Accession NZ_CP103972
Organism Escherichia coli strain DLI.5a

Toxin (Protein)


Gene name yoeB Uniprot ID D3GZ85
Locus tag NZD79_RS04210 Protein ID WP_000767820.1
Coordinates 831065..831319 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NZD79_RS04215 Protein ID WP_001259255.1
Coordinates 831316..831567 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZD79_RS04180 (826080) 826080..826307 - 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
NZD79_RS04185 (826321) 826321..827379 - 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
NZD79_RS04190 (827558) 827558..828916 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NZD79_RS04195 (828906) 828906..828968 - 63 WP_010723108.1 membrane protein YoeI -
NZD79_RS04200 (829183) 829183..830112 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NZD79_RS04205 (830158) 830158..830982 - 825 WP_000754756.1 SDR family oxidoreductase -
NZD79_RS04210 (831065) 831065..831319 - 255 WP_000767820.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NZD79_RS04215 (831316) 831316..831567 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NZD79_RS04220 (831851) 831851..831901 + 51 WP_001364200.1 his operon leader peptide -
NZD79_RS04225 (832047) 832047..832946 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
NZD79_RS04230 (832952) 832952..834256 + 1305 WP_001403690.1 histidinol dehydrogenase -
NZD79_RS04235 (834253) 834253..835323 + 1071 WP_001403691.1 histidinol-phosphate transaminase -
NZD79_RS04240 (835323) 835323..836390 + 1068 WP_001403692.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10182.64 Da        Isoelectric Point: 8.0353

>T256924 WP_000767820.1 NZ_CP103972:c831319-831065 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT256924 WP_001259255.1 NZ_CP103972:c831567-831316 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GZ85

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References