Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 7025297..7025973 Replicon chromosome
Accession NZ_CP103871
Organism Actinacidiphila bryophytorum strain DS3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYE86_RS30190 Protein ID WP_259441735.1
Coordinates 7025611..7025973 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYE86_RS30185 Protein ID WP_205044395.1
Coordinates 7025297..7025614 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYE86_RS30170 (NYE86_30170) 7021420..7023234 + 1815 WP_259441732.1 asparagine synthase (glutamine-hydrolyzing) -
NYE86_RS30175 (NYE86_30175) 7023231..7023956 + 726 WP_259441733.1 tyrosine-protein phosphatase -
NYE86_RS30180 (NYE86_30180) 7024443..7025168 + 726 WP_259441734.1 response regulator transcription factor -
NYE86_RS30185 (NYE86_30185) 7025297..7025614 - 318 WP_205044395.1 helix-turn-helix transcriptional regulator Antitoxin
NYE86_RS30190 (NYE86_30190) 7025611..7025973 - 363 WP_259441735.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYE86_RS30195 (NYE86_30195) 7026114..7026470 + 357 WP_259441736.1 YciI family protein -
NYE86_RS30200 (NYE86_30200) 7026613..7027868 + 1256 Protein_5961 RNA polymerase subunit sigma-24 -
NYE86_RS30205 (NYE86_30205) 7028055..7028726 + 672 WP_259441737.1 ABC transporter ATP-binding protein -
NYE86_RS30210 (NYE86_30210) 7028738..7029166 + 429 WP_259441738.1 S26 family signal peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13309.99 Da        Isoelectric Point: 4.5951

>T256874 WP_259441735.1 NZ_CP103871:c7025973-7025611 [Actinacidiphila bryophytorum]
VSGEWDIYLVDEVRDWIGGLDDAAHARVVQALDALAEGGPGLGRPLVDTIHGSVMANLKELRPGSVRILFAFDPWRSSIL
LVAGDKAGQWNEWYREAVPLAEQRYEMYVRERTKTEGAGS

Download         Length: 363 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11443.88 Da        Isoelectric Point: 8.7563

>AT256874 WP_205044395.1 NZ_CP103871:c7025614-7025297 [Actinacidiphila bryophytorum]
VSGFTRWQDIRAEHVERAGGEDAVRAGKEELLAVVTGRRLAELRRARGLTQQDVADRMGVTKGRVSQIERGQISGQEVLA
RFATALGGRLHQAIYFDDGDIAAIA

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References