Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 952086..952424 Replicon chromosome
Accession NZ_CP103860
Organism Staphylococcus aureus strain R3-8

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag NYR13_RS04820 Protein ID WP_011447039.1
Coordinates 952086..952262 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 952250..952424 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR13_RS04800 947321..951106 + 3786 WP_000582165.1 phage tail spike protein -
NYR13_RS04805 951096..951248 + 153 WP_001153681.1 hypothetical protein -
NYR13_RS04810 951295..951582 + 288 WP_001040261.1 hypothetical protein -
NYR13_RS04815 951640..951936 + 297 WP_000539688.1 DUF2951 domain-containing protein -
NYR13_RS04820 952086..952262 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 952250..952424 - 175 - - Antitoxin
NYR13_RS04830 952474..952728 + 255 WP_000611512.1 phage holin -
NYR13_RS04835 952740..953495 + 756 WP_000861038.1 CHAP domain-containing protein -
NYR13_RS04840 953686..954177 + 492 WP_000919350.1 staphylokinase -
NYR13_RS04845 954827..955162 + 336 Protein_952 SH3 domain-containing protein -
NYR13_RS04850 955257..955706 - 450 WP_251354221.1 chemotaxis-inhibiting protein CHIPS -
NYR13_RS04855 956391..956741 + 351 WP_000702263.1 complement inhibitor SCIN-A -
NYR13_RS04860 956794..957054 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb / sak / chp / scn 900793..956741 55948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T256820 WP_011447039.1 NZ_CP103860:952086-952262 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT256820 NZ_CP103860:c952424-952250 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References