Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 512493..513010 Replicon chromosome
Accession NZ_CP103860
Organism Staphylococcus aureus strain R3-8

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NYR13_RS02435 Protein ID WP_000113262.1
Coordinates 512744..513010 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag NYR13_RS02430 Protein ID WP_000584502.1
Coordinates 512493..512744 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR13_RS02400 (508194) 508194..508913 + 720 WP_000479576.1 amino acid ABC transporter permease -
NYR13_RS02405 (508910) 508910..509641 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NYR13_RS02410 (509738) 509738..510988 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
NYR13_RS02415 (511243) 511243..511602 + 360 WP_000819847.1 DUF4467 domain-containing protein -
NYR13_RS02420 (511621) 511621..512220 + 600 WP_000162813.1 DsbA family protein -
NYR13_RS02425 (512227) 512227..512328 + 102 WP_001791744.1 hypothetical protein -
NYR13_RS02430 (512493) 512493..512744 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NYR13_RS02435 (512744) 512744..513010 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NYR13_RS02440 (513045) 513045..513116 + 72 Protein_485 hypothetical protein -
NYR13_RS02445 (513305) 513305..514855 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NYR13_RS02450 (515041) 515041..515508 + 468 WP_000153344.1 SRPBCC domain-containing protein -
NYR13_RS02455 (515592) 515592..515774 + 183 WP_000230294.1 hypothetical protein -
NYR13_RS02460 (515991) 515991..516815 + 825 WP_000572040.1 formate/nitrite transporter family protein -
NYR13_RS02465 (517048) 517048..517584 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T256814 WP_000113262.1 NZ_CP103860:512744-513010 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT256814 WP_000584502.1 NZ_CP103860:512493-512744 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References