Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 455639..456162 Replicon chromosome
Accession NZ_CP103860
Organism Staphylococcus aureus strain R3-8

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag NYR13_RS02160 Protein ID WP_000074048.1
Coordinates 455896..456162 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag NYR13_RS02155 Protein ID WP_000587616.1
Coordinates 455639..455896 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR13_RS02130 (450719) 450719..451912 + 1194 WP_000675401.1 MFS transporter -
NYR13_RS02135 (452136) 452136..452885 - 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
NYR13_RS02140 (453080) 453080..454657 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
NYR13_RS02145 (454825) 454825..455280 - 456 WP_000732082.1 DUF1307 domain-containing protein -
NYR13_RS02150 (455339) 455339..455533 + 195 WP_001790145.1 hypothetical protein -
NYR13_RS02155 (455639) 455639..455896 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NYR13_RS02160 (455896) 455896..456162 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
NYR13_RS02165 (456517) 456517..457593 + 1077 WP_001076671.1 M42 family metallopeptidase -
NYR13_RS02170 (457841) 457841..458503 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
NYR13_RS02175 (458496) 458496..459272 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NYR13_RS02180 (459668) 459668..460855 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T256812 WP_000074048.1 NZ_CP103860:455896-456162 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT256812 WP_000587616.1 NZ_CP103860:455639-455896 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References