Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2555205..2555728 Replicon chromosome
Accession NZ_CP103850
Organism Staphylococcus aureus strain NRL 02/947

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag NYF25_RS12830 Protein ID WP_000074048.1
Coordinates 2555205..2555471 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag NYF25_RS12835 Protein ID WP_000587616.1
Coordinates 2555471..2555728 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYF25_RS12810 (2550512) 2550512..2551699 - 1188 WP_000026194.1 MFS transporter -
NYF25_RS12815 (2552095) 2552095..2552871 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NYF25_RS12820 (2552864) 2552864..2553526 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
NYF25_RS12825 (2553774) 2553774..2554850 - 1077 WP_001076671.1 M42 family metallopeptidase -
NYF25_RS12830 (2555205) 2555205..2555471 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
NYF25_RS12835 (2555471) 2555471..2555728 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NYF25_RS12840 (2555834) 2555834..2556028 - 195 WP_001790145.1 hypothetical protein -
NYF25_RS12845 (2556087) 2556087..2556542 + 456 WP_000732082.1 DUF1307 domain-containing protein -
NYF25_RS12850 (2556710) 2556710..2558287 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
NYF25_RS12855 (2558482) 2558482..2559231 + 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
NYF25_RS12860 (2559455) 2559455..2560648 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T256798 WP_000074048.1 NZ_CP103850:c2555471-2555205 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT256798 WP_000587616.1 NZ_CP103850:c2555728-2555471 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References