Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2498355..2498872 Replicon chromosome
Accession NZ_CP103850
Organism Staphylococcus aureus strain NRL 02/947

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NYF25_RS12555 Protein ID WP_000113262.1
Coordinates 2498355..2498621 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NYF25_RS12560 Protein ID WP_000584499.1
Coordinates 2498621..2498872 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYF25_RS12525 (2493784) 2493784..2494320 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NYF25_RS12530 (2494553) 2494553..2495377 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NYF25_RS12535 (2495594) 2495594..2495776 - 183 WP_000230294.1 hypothetical protein -
NYF25_RS12540 (2495860) 2495860..2496327 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NYF25_RS12545 (2496513) 2496513..2498060 - 1548 WP_001551849.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NYF25_RS12550 (2498249) 2498249..2498320 - 72 Protein_2424 hypothetical protein -
NYF25_RS12555 (2498355) 2498355..2498621 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NYF25_RS12560 (2498621) 2498621..2498872 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NYF25_RS12565 (2499037) 2499037..2499138 - 102 WP_001791744.1 hypothetical protein -
NYF25_RS12570 (2499145) 2499145..2499744 - 600 WP_000162813.1 DsbA family protein -
NYF25_RS12575 (2499763) 2499763..2500125 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NYF25_RS12580 (2500380) 2500380..2501629 + 1250 Protein_2430 FemA/FemB family glycyltransferase FmhA -
NYF25_RS12585 (2501726) 2501726..2502457 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NYF25_RS12590 (2502454) 2502454..2503173 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T256796 WP_000113262.1 NZ_CP103850:c2498621-2498355 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT256796 WP_000584499.1 NZ_CP103850:c2498872-2498621 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References