Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1855008..1855662 Replicon chromosome
Accession NZ_CP103834
Organism Actinobacillus genomosp.

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR63_RS08635 Protein ID WP_278226473.1
Coordinates 1855300..1855662 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR63_RS08630 Protein ID WP_275218140.1
Coordinates 1855008..1855316 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR63_RS08605 (NYR63_08600) 1850168..1850725 - 558 WP_279457153.1 septal ring lytic transglycosylase RlpA family protein -
NYR63_RS08610 (NYR63_08605) 1850900..1852024 - 1125 WP_279457154.1 rod shape-determining protein RodA -
NYR63_RS08615 (NYR63_08610) 1852017..1853981 - 1965 WP_279457155.1 penicillin-binding protein 2 -
NYR63_RS08620 (NYR63_08615) 1854064..1854531 - 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR63_RS08625 (NYR63_08620) 1854554..1854868 - 315 WP_005619625.1 ribosome silencing factor -
NYR63_RS08630 (NYR63_08625) 1855008..1855316 - 309 WP_275218140.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR63_RS08635 (NYR63_08630) 1855300..1855662 - 363 WP_278226473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR63_RS08640 (NYR63_08635) 1855841..1858435 - 2595 WP_279457156.1 DNA mismatch repair protein MutS -
NYR63_RS08645 (NYR63_08640) 1858601..1859350 - 750 WP_279457157.1 amino acid ABC transporter ATP-binding protein -
NYR63_RS08650 (NYR63_08645) 1859372..1860088 - 717 WP_005605560.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14067.13 Da        Isoelectric Point: 10.1215

>T256784 WP_278226473.1 NZ_CP103834:c1855662-1855300 [Actinobacillus genomosp. 1]
VKLVFVELPPFERYRQKHLSDEEYRHFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11628.49 Da        Isoelectric Point: 8.5450

>AT256784 WP_275218140.1 NZ_CP103834:c1855316-1855008 [Actinobacillus genomosp. 1]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References