Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1838907..1840255 Replicon chromosome
Accession NZ_CP103833
Organism Actinobacillus arthritidis strain CCUG24862

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag NYR89_RS08760 Protein ID WP_279445508.1
Coordinates 1839224..1840255 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag NYR89_RS08755 Protein ID WP_279445507.1
Coordinates 1838907..1839224 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR89_RS08725 (NYR89_08725) 1834320..1836413 - 2094 WP_279445503.1 factor H binding family protein -
NYR89_RS08730 (NYR89_08730) 1836552..1836965 + 414 WP_279445504.1 helix-turn-helix transcriptional regulator -
NYR89_RS08735 (NYR89_08735) 1837129..1837611 + 483 Protein_1697 hemerythrin domain-containing protein -
NYR89_RS08740 (NYR89_08740) 1837700..1838029 - 330 WP_005620515.1 SMR family transporter -
NYR89_RS08745 (NYR89_08745) 1838118..1838408 - 291 WP_279445505.1 YfcZ/YiiS family protein -
NYR89_RS08750 (NYR89_08750) 1838611..1838919 + 309 WP_279445506.1 helix-turn-helix transcriptional regulator -
NYR89_RS08755 (NYR89_08755) 1838907..1839224 + 318 WP_279445507.1 HipA N-terminal domain-containing protein Antitoxin
NYR89_RS08760 (NYR89_08760) 1839224..1840255 + 1032 WP_279445508.1 HipA domain-containing protein Toxin
NYR89_RS08765 (NYR89_08765) 1840302..1840934 - 633 WP_279445509.1 DUF533 domain-containing protein -
NYR89_RS08770 (NYR89_08770) 1841075..1841359 - 285 WP_279445510.1 putative quinol monooxygenase -
NYR89_RS08775 (NYR89_08775) 1841381..1842193 - 813 WP_279445511.1 urease accessory protein UreD -
NYR89_RS08780 (NYR89_08780) 1842359..1842994 - 636 WP_279441882.1 urease accessory protein UreG -
NYR89_RS08785 (NYR89_08785) 1843015..1843698 - 684 WP_279446671.1 urease accessory protein UreF -
NYR89_RS08790 (NYR89_08790) 1843710..1844273 - 564 WP_279445512.1 urease accessory protein UreE -
NYR89_RS08795 (NYR89_08795) 1844346..1844963 - 618 WP_279445513.1 glutathione S-transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-289)

Antitoxin

HipA, N-terminal subdomain 1

(8-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39388.95 Da        Isoelectric Point: 6.5050

>T256778 WP_279445508.1 NZ_CP103833:1839224-1840255 [Actinobacillus arthritidis]
MQNCRVLLTQLTDTEQKSGYSQKGLHYLTGQSDFIPVLPFSRQDFGTLEPRKQQGMSISGYQPKLQLVIHEKQFQSITHQ
GNYILKPSPEDYPFLAENEHATMQLMAKLGFIVPENGLIPFQTTSEQTEYAFVIKRFDRTNDNKPIHQEQLDGAMSVTEK
YGKTGSDNEQYISYEQAVKFILKHTENNLAQQQELFRRIVYAYLLGNNDLHLRNFSLIYAKTGEAKLAPIYDYVSVVPYK
AIFEGTILALPLLAKEEGNKELAHGFTTQYGEYIGQDFIEFGENIGLNRNVILKKLLPQILKEKAIVESVYQHSFMPLAH
QELVLKNYSRRLQLLQIIDEPSL

Download         Length: 1032 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12284.10 Da        Isoelectric Point: 6.8781

>AT256778 WP_279445507.1 NZ_CP103833:1838907-1839224 [Actinobacillus arthritidis]
MRRIKRSATVFLYDEPVGHLYQDDMGFHFSYFKDYVGIPLSLSLPVTQQHFHSEQLFPYFASLIPEGWLKAKYNVLQKID
EQDQFGLLLNNGENMLGAITIKREK

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References