Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2004069..2005417 Replicon chromosome
Accession NZ_CP103832
Organism Actinobacillus equuli subsp. haemolyticus strain 798

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag NYR88_RS09365 Protein ID WP_279437033.1
Coordinates 2004069..2005100 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag NYR88_RS09370 Protein ID WP_279444229.1
Coordinates 2005100..2005417 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR88_RS09330 (NYR88_09330) 1999301..1999918 + 618 WP_279444226.1 glutathione S-transferase -
NYR88_RS09335 (NYR88_09335) 1999991..2000554 + 564 WP_279444227.1 urease accessory protein UreE -
NYR88_RS09340 (NYR88_09340) 2000566..2001249 + 684 WP_279445005.1 urease accessory protein UreF -
NYR88_RS09345 (NYR88_09345) 2001270..2001905 + 636 WP_005613192.1 urease accessory protein UreG -
NYR88_RS09350 (NYR88_09350) 2002090..2002902 + 813 WP_279445006.1 urease accessory protein UreD -
NYR88_RS09355 (NYR88_09355) 2002924..2003214 + 291 WP_279444228.1 putative quinol monooxygenase -
NYR88_RS09360 (NYR88_09360) 2003391..2004023 + 633 WP_278226403.1 tellurite resistance TerB family protein -
NYR88_RS09365 (NYR88_09365) 2004069..2005100 - 1032 WP_279437033.1 HipA domain-containing protein Toxin
NYR88_RS09370 (NYR88_09370) 2005100..2005417 - 318 WP_279444229.1 HipA N-terminal domain-containing protein Antitoxin
NYR88_RS09375 (NYR88_09375) 2005405..2005713 - 309 WP_279437035.1 helix-turn-helix transcriptional regulator -
NYR88_RS09380 (NYR88_09380) 2005916..2006206 + 291 WP_279444230.1 YfcZ/YiiS family protein -
NYR88_RS09385 (NYR88_09385) 2006294..2006623 + 330 WP_039198285.1 SMR family transporter -
NYR88_RS09390 (NYR88_09390) 2006702..2007196 - 495 WP_279444231.1 hemerythrin domain-containing protein -
NYR88_RS09395 (NYR88_09395) 2007361..2008287 - 927 WP_015674211.1 ADP-glyceromanno-heptose 6-epimerase -
NYR88_RS09400 (NYR88_09400) 2008427..2008939 - 513 WP_039195517.1 peptide deformylase -
NYR88_RS09405 (NYR88_09405) 2009124..2010278 + 1155 WP_279444232.1 DNA-processing protein DprA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39591.22 Da        Isoelectric Point: 6.3975

>T256774 WP_279437033.1 NZ_CP103832:c2005100-2004069 [Actinobacillus equuli subsp. haemolyticus]
MQNCRVLLTQLTDTEQKSGYSQKGLYYLTGQSDFIPVLPFNRQDFSTLEPRKQQGMSISGYQPKLQLVIHEKQFQSIAQQ
GNYILKPSPEDYPFLAENEHATMQLMAKLGFVVPENGLIPFQSVSEQMEYAFVIKRFDRTNDNKSIHQEQLDGAMNVTEK
YGKTGSDNEQYISYEQAVKFILQHTENNLAQQQELFRRIVYAYLLGNNDLHLRNFSLVYSKTGEANLAPVYDYVSVVPYK
AIFEGTILALPLLVKEEGNKELAHGFTTKYGEYIGQDFIEFGENIGLNRKVILKKLLPQILKEKTIVESVYQRSFMPLEH
QALVLKNYYRRLQLLQILDEPSL

Download         Length: 1032 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12299.12 Da        Isoelectric Point: 5.5957

>AT256774 WP_279444229.1 NZ_CP103832:c2005417-2005100 [Actinobacillus equuli subsp. haemolyticus]
MRSIKRSAKVFLYDEPVGYLYQDDMGFHFSYFKDYIGMPLSLSLPVVQQHFHSEQLFPYFASLIPEGWLKAKYNVLQKID
EQDQFGLLLNNGENMLGAITIKREE

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References