Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1950803..1951457 Replicon chromosome
Accession NZ_CP103832
Organism Actinobacillus equuli subsp. haemolyticus strain 798

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR88_RS09075 Protein ID WP_278226473.1
Coordinates 1950803..1951165 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR88_RS09080 Protein ID WP_275218140.1
Coordinates 1951149..1951457 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR88_RS09060 (NYR88_09060) 1946373..1947090 + 718 Protein_1749 amino acid ABC transporter permease -
NYR88_RS09065 (NYR88_09065) 1947112..1947861 + 750 WP_279444203.1 amino acid ABC transporter ATP-binding protein -
NYR88_RS09070 (NYR88_09070) 1948027..1950621 + 2595 WP_279444204.1 DNA mismatch repair protein MutS -
NYR88_RS09075 (NYR88_09075) 1950803..1951165 + 363 WP_278226473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR88_RS09080 (NYR88_09080) 1951149..1951457 + 309 WP_275218140.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR88_RS09085 (NYR88_09085) 1951597..1951911 + 315 WP_005619625.1 ribosome silencing factor -
NYR88_RS09090 (NYR88_09090) 1951934..1952401 + 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR88_RS09095 (NYR88_09095) 1952484..1954454 + 1971 WP_279444205.1 penicillin-binding protein 2 -
NYR88_RS09100 (NYR88_09100) 1954447..1955571 + 1125 WP_039198374.1 rod shape-determining protein RodA -
NYR88_RS09105 (NYR88_09105) 1955746..1956312 + 567 WP_279444206.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14067.13 Da        Isoelectric Point: 10.1215

>T256773 WP_278226473.1 NZ_CP103832:1950803-1951165 [Actinobacillus equuli subsp. haemolyticus]
VKLVFVELPPFERYRQKHLSDEEYRHFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11628.49 Da        Isoelectric Point: 8.5450

>AT256773 WP_275218140.1 NZ_CP103832:1951149-1951457 [Actinobacillus equuli subsp. haemolyticus]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References