256770

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2019101..2020449 Replicon chromosome
Accession NZ_CP103831
Organism Actinobacillus equuli subsp. haemolyticus strain 1812

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag NYR87_RS09325 Protein ID WP_279480730.1
Coordinates 2019101..2020132 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag NYR87_RS09330 Protein ID WP_279444229.1
Coordinates 2020132..2020449 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR87_RS09295 (NYR87_09290) 2015024..2015587 + 564 WP_279480721.1 urease accessory protein UreE -
NYR87_RS09300 (NYR87_09295) 2015599..2016282 + 684 WP_164997545.1 urease accessory protein UreF -
NYR87_RS09305 (NYR87_09300) 2016303..2016938 + 636 WP_005613192.1 urease accessory protein UreG -
NYR87_RS09310 (NYR87_09305) 2017123..2017935 + 813 WP_279480723.1 urease accessory protein UreD -
NYR87_RS09315 (NYR87_09310) 2017957..2018250 + 294 WP_279480726.1 putative quinol monooxygenase -
NYR87_RS09320 (NYR87_09315) 2018423..2019055 + 633 WP_005613185.1 tellurite resistance TerB family protein -
NYR87_RS09325 (NYR87_09320) 2019101..2020132 - 1032 WP_279480730.1 HipA domain-containing protein Toxin
NYR87_RS09330 (NYR87_09325) 2020132..2020449 - 318 WP_279444229.1 HipA N-terminal domain-containing protein Antitoxin
NYR87_RS09335 (NYR87_09330) 2020437..2020745 - 309 WP_279437035.1 helix-turn-helix transcriptional regulator -
NYR87_RS09340 (NYR87_09335) 2020948..2021238 + 291 WP_005602339.1 YfcZ/YiiS family protein -
NYR87_RS09345 (NYR87_09340) 2021326..2021655 + 330 WP_039198285.1 SMR family transporter -
NYR87_RS09350 (NYR87_09345) 2021734..2022228 - 495 WP_279480732.1 hemerythrin domain-containing protein -
NYR87_RS09355 (NYR87_09350) 2022387..2023313 - 927 WP_015674211.1 ADP-glyceromanno-heptose 6-epimerase -
NYR87_RS09360 (NYR87_09355) 2023453..2023965 - 513 WP_005599196.1 peptide deformylase -
NYR87_RS09365 (NYR87_09360) 2024150..2025304 + 1155 WP_279480735.1 DNA-processing protein DprA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39605.24 Da        Isoelectric Point: 6.3975

>T256770 WP_279480730.1 NZ_CP103831:c2020132-2019101 [Actinobacillus equuli subsp. haemolyticus]
MQNCRVLLTQLTDTEQKSGYSQKGLYYLTGQSDFIPVLPFNRQDFSTLEPRKQQGMSISGYQPKLQLVIHEKQFQSIAQQ
GNYILKPSPEDYPFLAENEHATMQLMAKLGFVVPENGLIPFQSVSEQMEYAFVIKRFDRTNDNKSIHQEQLDGAMNITEK
YGKTGSDNEQYISYEQAVKFILQHTENNLAQQQELFRRIVYAYLLGNNDLHLRNFSLVYSKTGEANLAPVYDYVSVVPYK
AIFEGTILALPLLVKEEGNKELAHGFTTKYGEYIGQDFIEFGENIGLNRKVILKKLLPQILKEKTIVESVYQRSFMPLEH
QALVLKNYYRRLQLLQILDEPSL

Download         Length: 1032 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12299.12 Da        Isoelectric Point: 5.5957

>AT256770 WP_279444229.1 NZ_CP103831:c2020449-2020132 [Actinobacillus equuli subsp. haemolyticus]
MRSIKRSAKVFLYDEPVGYLYQDDMGFHFSYFKDYIGMPLSLSLPVVQQHFHSEQLFPYFASLIPEGWLKAKYNVLQKID
EQDQFGLLLNNGENMLGAITIKREE

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References