Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 2040276..2040930 Replicon chromosome
Accession NZ_CP103830
Organism Actinobacillus equuli subsp. equuli strain 2499

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR86_RS09285 Protein ID WP_278226473.1
Coordinates 2040276..2040638 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR86_RS09290 Protein ID WP_275218140.1
Coordinates 2040622..2040930 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR86_RS09270 (NYR86_09270) 2035847..2036563 + 717 WP_005608982.1 amino acid ABC transporter permease -
NYR86_RS09275 (NYR86_09275) 2036585..2037334 + 750 WP_015674150.1 amino acid ABC transporter ATP-binding protein -
NYR86_RS09280 (NYR86_09280) 2037500..2040094 + 2595 WP_279623193.1 DNA mismatch repair protein MutS -
NYR86_RS09285 (NYR86_09285) 2040276..2040638 + 363 WP_278226473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR86_RS09290 (NYR86_09290) 2040622..2040930 + 309 WP_275218140.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR86_RS09295 (NYR86_09295) 2041070..2041384 + 315 WP_005619625.1 ribosome silencing factor -
NYR86_RS09300 (NYR86_09300) 2041407..2041874 + 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR86_RS09305 (NYR86_09305) 2041957..2043927 + 1971 WP_039198373.1 penicillin-binding protein 2 -
NYR86_RS09310 (NYR86_09310) 2043920..2045044 + 1125 WP_039198374.1 rod shape-determining protein RodA -
NYR86_RS09315 (NYR86_09315) 2045219..2045785 + 567 WP_039198375.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14067.13 Da        Isoelectric Point: 10.1215

>T256766 WP_278226473.1 NZ_CP103830:2040276-2040638 [Actinobacillus equuli subsp. equuli]
VKLVFVELPPFERYRQKHLSDEEYRHFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11628.49 Da        Isoelectric Point: 8.5450

>AT256766 WP_275218140.1 NZ_CP103830:2040622-2040930 [Actinobacillus equuli subsp. equuli]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References