Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1941806..1942456 Replicon chromosome
Accession NZ_CP103829
Organism Actinobacillus equuli subsp. haemolyticus strain 2863

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR66_RS09015 Protein ID WP_279440726.1
Coordinates 1941806..1942147 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR66_RS09020 Protein ID WP_279440727.1
Coordinates 1942148..1942456 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR66_RS09000 (NYR66_09005) 1937377..1938093 + 717 WP_279455865.1 amino acid ABC transporter permease -
NYR66_RS09005 (NYR66_09010) 1938115..1938864 + 750 WP_015674150.1 amino acid ABC transporter ATP-binding protein -
NYR66_RS09010 (NYR66_09015) 1939030..1941624 + 2595 WP_279455866.1 DNA mismatch repair protein MutS -
NYR66_RS09015 (NYR66_09020) 1941806..1942147 + 342 WP_279440726.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR66_RS09020 (NYR66_09025) 1942148..1942456 + 309 WP_279440727.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR66_RS09025 (NYR66_09030) 1942596..1942910 + 315 WP_005619625.1 ribosome silencing factor -
NYR66_RS09030 (NYR66_09035) 1942933..1943400 + 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR66_RS09035 (NYR66_09040) 1943483..1945453 + 1971 WP_279440728.1 penicillin-binding protein 2 -
NYR66_RS09040 (NYR66_09045) 1945446..1946570 + 1125 WP_015674144.1 rod shape-determining protein RodA -
NYR66_RS09045 (NYR66_09050) 1946745..1947311 + 567 WP_039198375.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(46-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13316.25 Da        Isoelectric Point: 9.8493

>T256764 WP_279440726.1 NZ_CP103829:1941806-1942147 [Actinobacillus equuli subsp. haemolyticus]
VKLVFVELPPFDKFRYENLTDDDYREFQEYLMNNPEAGDIVQGVNGLRKIRISTQAKGKKGGARVIYYYYVRGSQIWLFT
GYNKSRKIDLNSMERKAFSKVLEHLKNIADREL

Download         Length: 342 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11616.48 Da        Isoelectric Point: 7.2032

>AT256764 WP_279440727.1 NZ_CP103829:1942148-1942456 [Actinobacillus equuli subsp. haemolyticus]
MGRLFDDLMEGAEALEQYLQGKITLRTTVLEKPEPIELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QAVLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References