256761

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1993921..1994575 Replicon chromosome
Accession NZ_CP103828
Organism Actinobacillus equuli subsp. equuli strain 3009

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR83_RS09100 Protein ID WP_278226473.1
Coordinates 1993921..1994283 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR83_RS09105 Protein ID WP_275218140.1
Coordinates 1994267..1994575 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR83_RS09085 (NYR83_09085) 1989480..1990196 + 717 WP_005605560.1 amino acid ABC transporter permease -
NYR83_RS09090 (NYR83_09090) 1990218..1990967 + 750 WP_015674150.1 amino acid ABC transporter ATP-binding protein -
NYR83_RS09095 (NYR83_09095) 1991145..1993739 + 2595 WP_279438388.1 DNA mismatch repair protein MutS -
NYR83_RS09100 (NYR83_09100) 1993921..1994283 + 363 WP_278226473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR83_RS09105 (NYR83_09105) 1994267..1994575 + 309 WP_275218140.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR83_RS09110 (NYR83_09110) 1994715..1995029 + 315 WP_005619625.1 ribosome silencing factor -
NYR83_RS09115 (NYR83_09115) 1995052..1995519 + 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR83_RS09120 (NYR83_09120) 1995602..1997572 + 1971 WP_279443128.1 penicillin-binding protein 2 -
NYR83_RS09125 (NYR83_09125) 1997565..1998689 + 1125 WP_039198374.1 rod shape-determining protein RodA -
NYR83_RS09130 (NYR83_09130) 1998864..1999430 + 567 WP_039198375.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14067.13 Da        Isoelectric Point: 10.1215

>T256761 WP_278226473.1 NZ_CP103828:1993921-1994283 [Actinobacillus equuli subsp. equuli]
VKLVFVELPPFERYRQKHLSDEEYRHFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11628.49 Da        Isoelectric Point: 8.5450

>AT256761 WP_275218140.1 NZ_CP103828:1994267-1994575 [Actinobacillus equuli subsp. equuli]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References