25676

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 7046238..7046914 Replicon chromosome
Accession NC_016109
Organism Kitasatospora setae KM-6054

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KSE_RS31030 Protein ID WP_033259005.1
Coordinates 7046546..7046914 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KSE_RS31025 Protein ID WP_033258994.1
Coordinates 7046238..7046543 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSE_RS30995 7042747..7043256 + 510 WP_014139325.1 hypothetical protein -
KSE_RS31000 7043272..7043679 + 408 WP_014139326.1 hypothetical protein -
KSE_RS31005 7044015..7044290 + 276 WP_014139327.1 hypothetical protein -
KSE_RS31010 7044544..7044966 + 423 WP_014139328.1 secondary thiamine-phosphate synthase enzyme YjbQ -
KSE_RS31015 7045067..7045306 + 240 WP_014139329.1 hypothetical protein -
KSE_RS31020 7045310..7046230 + 921 WP_014139330.1 alpha/beta hydrolase -
KSE_RS31025 7046238..7046543 - 306 WP_033258994.1 XRE family transcriptional regulator Antitoxin
KSE_RS31030 7046546..7046914 - 369 WP_033259005.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KSE_RS31035 7046968..7050000 - 3033 WP_014139333.1 SMC family ATPase -
KSE_RS31040 7050026..7051198 - 1173 WP_014139334.1 exonuclease SbcCD subunit D -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-84)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13945.74 Da        Isoelectric Point: 4.7374

>T25676 WP_033259005.1 NC_016109:c7046914-7046546 [Kitasatospora setae KM-6054]
VAWEVSLHEAVVAWFIRLSEDEPEVADQVAAAVDKLAEEGPTLGRPLVDRIKRSRHHHMKELRPRVGGESEIRILFAFDP
EREAILLVAGDKSGQWNLWYDLNIPIADDRFDRHLDALKEGE

Download         Length: 369 bp

>T25676 NC_016109:c7046914-7046546 [Kitasatospora setae KM-6054]
GTGGCATGGGAAGTCTCACTGCACGAAGCGGTGGTCGCCTGGTTCATCAGGCTGAGCGAGGACGAACCGGAGGTCGCGGA
CCAGGTCGCCGCCGCCGTCGACAAGCTCGCGGAGGAGGGGCCGACCCTCGGGCGGCCGCTGGTCGACCGGATCAAACGGT
CCAGACACCATCACATGAAGGAACTGCGCCCCCGGGTCGGTGGCGAGAGCGAGATCCGCATCCTGTTCGCGTTCGATCCG
GAACGGGAGGCGATCCTGCTCGTCGCGGGCGACAAGTCCGGGCAGTGGAACCTGTGGTACGACCTGAACATCCCGATCGC
GGATGACCGGTTCGACCGGCATCTCGACGCGCTCAAGGAGGGCGAGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11587.02 Da        Isoelectric Point: 5.7830

>AT25676 WP_033258994.1 NC_016109:c7046543-7046238 [Kitasatospora setae KM-6054]
MARSWKDVRTEVVTDEERVAAHRTRLDAEVRAYRLAEIRREQDLTQTEVAELIGVTQPNVSRLERGDLEGTSLGTLREYV
EALGGRLHLVADFGDRRLRIQ

Download         Length: 306 bp

>AT25676 NC_016109:c7046543-7046238 [Kitasatospora setae KM-6054]
ATGGCCAGATCCTGGAAGGACGTCCGCACCGAAGTCGTGACCGACGAGGAGCGGGTCGCGGCCCACCGCACCCGGCTCGA
CGCCGAGGTGCGCGCCTACCGGCTCGCCGAGATCCGCCGGGAGCAGGACCTGACCCAGACCGAGGTCGCGGAGCTGATCG
GCGTCACCCAGCCCAACGTCTCCCGCCTGGAGCGCGGTGACCTCGAAGGCACCTCACTGGGCACCCTCCGCGAGTACGTC
GAGGCCCTCGGCGGCCGGCTCCACCTGGTCGCGGACTTCGGCGACCGCCGCCTGCGCATCCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References