256754

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2030374..2031722 Replicon chromosome
Accession NZ_CP103826
Organism Actinobacillus equuli subsp. haemolyticus strain 3113

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag NYR81_RS09545 Protein ID WP_279437033.1
Coordinates 2030374..2031405 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag NYR81_RS09550 Protein ID WP_279437034.1
Coordinates 2031405..2031722 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR81_RS09510 (NYR81_09510) 2025770..2026453 + 684 WP_279442800.1 urease accessory protein UreF -
NYR81_RS09515 (NYR81_09515) 2026465..2026941 + 477 WP_279441880.1 PIN domain-containing protein -
NYR81_RS09520 (NYR81_09520) 2026983..2027594 + 612 WP_279441881.1 hypothetical protein -
NYR81_RS09525 (NYR81_09525) 2027609..2028244 + 636 WP_279441882.1 urease accessory protein UreG -
NYR81_RS09530 (NYR81_09530) 2028411..2029223 + 813 WP_279479283.1 urease accessory protein UreD -
NYR81_RS09535 (NYR81_09535) 2029245..2029529 + 285 WP_279441884.1 putative quinol monooxygenase -
NYR81_RS09540 (NYR81_09540) 2029696..2030328 + 633 WP_279479284.1 tellurite resistance TerB family protein -
NYR81_RS09545 (NYR81_09545) 2030374..2031405 - 1032 WP_279437033.1 HipA domain-containing protein Toxin
NYR81_RS09550 (NYR81_09550) 2031405..2031722 - 318 WP_279437034.1 HipA N-terminal domain-containing protein Antitoxin
NYR81_RS09555 (NYR81_09555) 2031710..2032018 - 309 WP_279437035.1 helix-turn-helix transcriptional regulator -
NYR81_RS09560 (NYR81_09560) 2032221..2032511 + 291 WP_005602339.1 YfcZ/YiiS family protein -
NYR81_RS09565 (NYR81_09565) 2032599..2032928 + 330 WP_279441886.1 SMR family transporter -
NYR81_RS09570 (NYR81_09570) 2033007..2033501 - 495 WP_279441887.1 hemerythrin domain-containing protein -
NYR81_RS09575 (NYR81_09575) 2033666..2034592 - 927 WP_015674211.1 ADP-glyceromanno-heptose 6-epimerase -
NYR81_RS09580 (NYR81_09580) 2034732..2035244 - 513 WP_039195517.1 peptide deformylase -
NYR81_RS09585 (NYR81_09585) 2035429..2036583 + 1155 WP_279479286.1 DNA-processing protein DprA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39591.22 Da        Isoelectric Point: 6.3975

>T256754 WP_279437033.1 NZ_CP103826:c2031405-2030374 [Actinobacillus equuli subsp. haemolyticus]
MQNCRVLLTQLTDTEQKSGYSQKGLYYLTGQSDFIPVLPFNRQDFSTLEPRKQQGMSISGYQPKLQLVIHEKQFQSIAQQ
GNYILKPSPEDYPFLAENEHATMQLMAKLGFVVPENGLIPFQSVSEQMEYAFVIKRFDRTNDNKSIHQEQLDGAMNVTEK
YGKTGSDNEQYISYEQAVKFILQHTENNLAQQQELFRRIVYAYLLGNNDLHLRNFSLVYSKTGEANLAPVYDYVSVVPYK
AIFEGTILALPLLVKEEGNKELAHGFTTKYGEYIGQDFIEFGENIGLNRKVILKKLLPQILKEKTIVESVYQRSFMPLEH
QALVLKNYYRRLQLLQILDEPSL

Download         Length: 1032 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12291.10 Da        Isoelectric Point: 4.8047

>AT256754 WP_279437034.1 NZ_CP103826:c2031722-2031405 [Actinobacillus equuli subsp. haemolyticus]
MRSIKRSAKVFLYDEPVGYLYQDEMGFHFSYFKDYIGMPLSLSLPVVQQDFHSEQLFPYFASLIPEGWLKAKYNVLQKID
EQDQFGLLLNNGENMLGAITIKREE

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References