Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1975949..1976599 Replicon chromosome
Accession NZ_CP103826
Organism Actinobacillus equuli subsp. haemolyticus strain 3113

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR81_RS09245 Protein ID WP_279441848.1
Coordinates 1975949..1976290 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR81_RS09250 Protein ID WP_279439545.1
Coordinates 1976291..1976599 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR81_RS09230 (NYR81_09230) 1971518..1972235 + 718 Protein_1781 amino acid ABC transporter permease -
NYR81_RS09235 (NYR81_09235) 1972257..1973007 + 751 Protein_1782 amino acid ABC transporter ATP-binding protein -
NYR81_RS09240 (NYR81_09240) 1973173..1975767 + 2595 WP_279479271.1 DNA mismatch repair protein MutS -
NYR81_RS09245 (NYR81_09245) 1975949..1976290 + 342 WP_279441848.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR81_RS09250 (NYR81_09250) 1976291..1976599 + 309 WP_279439545.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR81_RS09255 (NYR81_09255) 1976739..1977053 + 315 WP_005619625.1 ribosome silencing factor -
NYR81_RS09260 (NYR81_09260) 1977076..1977543 + 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR81_RS09265 (NYR81_09265) 1977626..1979596 + 1971 WP_015674145.1 penicillin-binding protein 2 -
NYR81_RS09270 (NYR81_09270) 1979589..1980713 + 1125 WP_015674144.1 rod shape-determining protein RodA -
NYR81_RS09275 (NYR81_09275) 1980888..1981454 + 567 WP_015674143.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(46-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13376.37 Da        Isoelectric Point: 9.8493

>T256753 WP_279441848.1 NZ_CP103826:1975949-1976290 [Actinobacillus equuli subsp. haemolyticus]
MKLVFVELPPFDKFRYENLTDDDYREFQEYLMNNPEVGDIVQGVNGLRKIRISTQAKGKKGGARVIYYYYVRGSQIWLFT
GYNKSRKIDLNSMERKAFSKVLEHLKNIADREL

Download         Length: 342 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11618.45 Da        Isoelectric Point: 7.2032

>AT256753 WP_279439545.1 NZ_CP103826:1976291-1976599 [Actinobacillus equuli subsp. haemolyticus]
MGRLFDDLMEGAEALEQYLQGKITLRTTVLEKPEPIELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References