256749

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2015738..2016978 Replicon chromosome
Accession NZ_CP103825
Organism Actinobacillus equuli subsp. haemolyticus strain 3282

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag NYR80_RS09320 Protein ID WP_279622863.1
Coordinates 2015738..2016661 (-) Length 308 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag NYR80_RS09325 Protein ID WP_279437034.1
Coordinates 2016661..2016978 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR80_RS09285 (NYR80_09290) 2010877..2011494 + 618 WP_039198291.1 glutathione S-transferase -
NYR80_RS09290 (NYR80_09295) 2011567..2012130 + 564 WP_279438414.1 urease accessory protein UreE -
NYR80_RS09295 (NYR80_09300) 2012142..2012825 + 684 WP_279439193.1 urease accessory protein UreF -
NYR80_RS09300 (NYR80_09305) 2012846..2013481 + 636 WP_009874590.1 urease accessory protein UreG -
NYR80_RS09305 (NYR80_09310) 2013666..2014478 + 813 WP_039199081.1 urease accessory protein UreD -
NYR80_RS09310 (NYR80_09315) 2014500..2014784 + 285 WP_279438415.1 putative quinol monooxygenase -
NYR80_RS09315 (NYR80_09320) 2014951..2015583 + 633 WP_279438416.1 DUF533 domain-containing protein -
NYR80_RS09320 (NYR80_09325) 2015738..2016661 - 924 WP_279622863.1 HipA domain-containing protein Toxin
NYR80_RS09325 (NYR80_09330) 2016661..2016978 - 318 WP_279437034.1 HipA N-terminal domain-containing protein Antitoxin
NYR80_RS09330 (NYR80_09335) 2016966..2017274 - 309 WP_279437035.1 helix-turn-helix transcriptional regulator -
NYR80_RS09335 (NYR80_09340) 2017477..2017767 + 291 WP_005602339.1 YfcZ/YiiS family protein -
NYR80_RS09340 (NYR80_09345) 2017855..2018184 + 330 WP_039198285.1 SMR family transporter -
NYR80_RS09345 (NYR80_09350) 2018263..2018757 - 495 WP_279438417.1 hemerythrin domain-containing protein -
NYR80_RS09350 (NYR80_09355) 2018916..2019842 - 927 WP_015674211.1 ADP-glyceromanno-heptose 6-epimerase -
NYR80_RS09355 (NYR80_09360) 2019982..2020494 - 513 WP_039195517.1 peptide deformylase -
NYR80_RS09360 (NYR80_09365) 2020679..2021833 + 1155 WP_279438418.1 DNA-processing protein DprA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 308 a.a.        Molecular weight: 35220.01 Da        Isoelectric Point: 5.9770

>T256749 WP_279622863.1 NZ_CP103825:c2016661-2015738 [Actinobacillus equuli subsp. haemolyticus]
MQNCRVLLTQLTDTEQKSGYSQKGLYYLTGQSDFIPVLPFNRQDFSTLEPRKQQGMSISGYQPKLQLVIHEKQFQSIAQQ
GNYILKPSPEDYPFLAENEHATMQLMAKLGFVVPENGLIPFQSVSEQMEYAFVIKRFDRTNDNKSIHQEQLDGAMNVTEK
YGKTGSDNEQYISYEQAVKFILQHTENNLAQQQELFRRIVYAYLLGNNDLHLRNFSLVYSKTGEANLAPVYDYVSVVPYK
AIFEGTILALPLLVKEEGNKELAHGFTTKYGEYIGQDFIEFGENIGLNRKVILKKLLPQILKEKNDS

Download         Length: 924 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12291.10 Da        Isoelectric Point: 4.8047

>AT256749 WP_279437034.1 NZ_CP103825:c2016978-2016661 [Actinobacillus equuli subsp. haemolyticus]
MRSIKRSAKVFLYDEPVGYLYQDEMGFHFSYFKDYIGMPLSLSLPVVQQDFHSEQLFPYFASLIPEGWLKAKYNVLQKID
EQDQFGLLLNNGENMLGAITIKREE

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References