Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1960558..1961212 Replicon chromosome
Accession NZ_CP103825
Organism Actinobacillus equuli subsp. haemolyticus strain 3282

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR80_RS09025 Protein ID WP_279438389.1
Coordinates 1960558..1960920 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR80_RS09030 Protein ID WP_275218140.1
Coordinates 1960904..1961212 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR80_RS09010 (NYR80_09015) 1956129..1956845 + 717 WP_005605560.1 amino acid ABC transporter permease -
NYR80_RS09015 (NYR80_09020) 1956867..1957616 + 750 WP_015674150.1 amino acid ABC transporter ATP-binding protein -
NYR80_RS09020 (NYR80_09025) 1957782..1960376 + 2595 WP_279438388.1 DNA mismatch repair protein MutS -
NYR80_RS09025 (NYR80_09030) 1960558..1960920 + 363 WP_279438389.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR80_RS09030 (NYR80_09035) 1960904..1961212 + 309 WP_275218140.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR80_RS09035 (NYR80_09040) 1961352..1961666 + 315 WP_005619625.1 ribosome silencing factor -
NYR80_RS09040 (NYR80_09045) 1961689..1962156 + 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR80_RS09045 (NYR80_09050) 1962239..1964209 + 1971 WP_279438390.1 penicillin-binding protein 2 -
NYR80_RS09050 (NYR80_09055) 1964202..1965326 + 1125 WP_039198374.1 rod shape-determining protein RodA -
NYR80_RS09055 (NYR80_09060) 1965501..1966067 + 567 WP_039198375.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14044.10 Da        Isoelectric Point: 10.1214

>T256748 WP_279438389.1 NZ_CP103825:1960558-1960920 [Actinobacillus equuli subsp. haemolyticus]
VKLVFVELPPFERYRQKHLSDEEYRNFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11628.49 Da        Isoelectric Point: 8.5450

>AT256748 WP_275218140.1 NZ_CP103825:1960904-1961212 [Actinobacillus equuli subsp. haemolyticus]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References