Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1208265..1208910 Replicon chromosome
Accession NZ_CP103825
Organism Actinobacillus equuli subsp. haemolyticus strain 3282

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR80_RS05420 Protein ID WP_081578050.1
Coordinates 1208566..1208910 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR80_RS05415 Protein ID WP_279439166.1
Coordinates 1208265..1208561 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR80_RS05390 (NYR80_05395) 1203442..1204446 - 1005 WP_279439163.1 Holliday junction branch migration DNA helicase RuvB -
NYR80_RS05395 (NYR80_05400) 1204465..1205070 - 606 WP_279439164.1 Holliday junction branch migration protein RuvA -
NYR80_RS05400 (NYR80_05405) 1205212..1205979 - 768 WP_014991849.1 spermidine/putrescine ABC transporter permease PotC -
NYR80_RS05405 (NYR80_05410) 1205979..1206845 - 867 WP_279439165.1 spermidine/putrescine ABC transporter permease PotB -
NYR80_RS05410 (NYR80_05415) 1206832..1207947 - 1116 WP_039197327.1 spermidine/putrescine ABC transporter ATP-binding protein PotA -
NYR80_RS05415 (NYR80_05420) 1208265..1208561 - 297 WP_279439166.1 NadS family protein Antitoxin
NYR80_RS05420 (NYR80_05425) 1208566..1208910 - 345 WP_081578050.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR80_RS05425 (NYR80_05430) 1209116..1211134 + 2019 WP_279622833.1 DNA helicase Rep -
NYR80_RS05430 (NYR80_05435) 1211223..1211975 - 753 WP_279622834.1 TatD family hydrolase -
NYR80_RS05435 (NYR80_05440) 1212069..1213220 - 1152 WP_014991856.1 methionine adenosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(50-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13358.38 Da        Isoelectric Point: 7.9875

>T256746 WP_081578050.1 NZ_CP103825:c1208910-1208566 [Actinobacillus equuli subsp. haemolyticus]
MNSDEYLTFVEVGTFEEDRKQLMADDEYQLFQAYLLEHYELGDFIPHTGGCQKIRWRLPENNKGKSAGVRIIYYVRSLTG
RIYLITMYGKSEKVNLNAREKAIMKKIISRLIGE

Download         Length: 345 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.05 Da        Isoelectric Point: 10.4778

>AT256746 WP_279439166.1 NZ_CP103825:c1208561-1208265 [Actinobacillus equuli subsp. haemolyticus]
MEKRLFERLVQGLEEMVAIEKGEVEVPSHRIHVHKIPNTKAIRTQHHLKQAEFAQLLGVSTNLVQSWEIGRRVPNGAARK
LLAIIEQQPNLVPLLQSL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References