256743

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 427450..428104 Replicon chromosome
Accession NZ_CP103824
Organism Actinobacillus equuli subsp. haemolyticus strain 3524

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR79_RS02035 Protein ID WP_278226473.1
Coordinates 427742..428104 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR79_RS02030 Protein ID WP_275218140.1
Coordinates 427450..427758 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR79_RS02005 (NYR79_02005) 422594..423160 - 567 WP_039198375.1 septal ring lytic transglycosylase RlpA family protein -
NYR79_RS02010 (NYR79_02010) 423335..424459 - 1125 WP_039198374.1 rod shape-determining protein RodA -
NYR79_RS02015 (NYR79_02015) 424452..426422 - 1971 WP_039198373.1 penicillin-binding protein 2 -
NYR79_RS02020 (NYR79_02020) 426505..426972 - 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR79_RS02025 (NYR79_02025) 426995..427309 - 315 WP_005619625.1 ribosome silencing factor -
NYR79_RS02030 (NYR79_02030) 427450..427758 - 309 WP_275218140.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR79_RS02035 (NYR79_02035) 427742..428104 - 363 WP_278226473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR79_RS02040 (NYR79_02040) 428286..430880 - 2595 WP_279455153.1 DNA mismatch repair protein MutS -
NYR79_RS02045 (NYR79_02045) 431046..431795 - 750 WP_279455154.1 amino acid ABC transporter ATP-binding protein -
NYR79_RS02050 (NYR79_02050) 431817..432533 - 717 WP_005605560.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14067.13 Da        Isoelectric Point: 10.1215

>T256743 WP_278226473.1 NZ_CP103824:c428104-427742 [Actinobacillus equuli subsp. haemolyticus]
VKLVFVELPPFERYRQKHLSDEEYRHFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11628.49 Da        Isoelectric Point: 8.5450

>AT256743 WP_275218140.1 NZ_CP103824:c427758-427450 [Actinobacillus equuli subsp. haemolyticus]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References