256740

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 2139533..2140183 Replicon chromosome
Accession NZ_CP103822
Organism Actinobacillus equuli subsp. haemolyticus strain 3617

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR77_RS09930 Protein ID WP_279440726.1
Coordinates 2139533..2139874 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR77_RS09935 Protein ID WP_279440727.1
Coordinates 2139875..2140183 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR77_RS09915 (NYR77_09910) 2135104..2135820 + 717 WP_005608982.1 amino acid ABC transporter permease -
NYR77_RS09920 (NYR77_09915) 2135842..2136591 + 750 WP_015674150.1 amino acid ABC transporter ATP-binding protein -
NYR77_RS09925 (NYR77_09920) 2136757..2139351 + 2595 WP_279440725.1 DNA mismatch repair protein MutS -
NYR77_RS09930 (NYR77_09925) 2139533..2139874 + 342 WP_279440726.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR77_RS09935 (NYR77_09930) 2139875..2140183 + 309 WP_279440727.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR77_RS09940 (NYR77_09935) 2140323..2140637 + 315 WP_005619625.1 ribosome silencing factor -
NYR77_RS09945 (NYR77_09940) 2140660..2141127 + 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR77_RS09950 (NYR77_09945) 2141210..2143180 + 1971 WP_279440728.1 penicillin-binding protein 2 -
NYR77_RS09955 (NYR77_09950) 2143173..2144297 + 1125 WP_015674144.1 rod shape-determining protein RodA -
NYR77_RS09960 (NYR77_09955) 2144472..2145038 + 567 WP_039198375.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(46-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13316.25 Da        Isoelectric Point: 9.8493

>T256740 WP_279440726.1 NZ_CP103822:2139533-2139874 [Actinobacillus equuli subsp. haemolyticus]
VKLVFVELPPFDKFRYENLTDDDYREFQEYLMNNPEAGDIVQGVNGLRKIRISTQAKGKKGGARVIYYYYVRGSQIWLFT
GYNKSRKIDLNSMERKAFSKVLEHLKNIADREL

Download         Length: 342 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11616.48 Da        Isoelectric Point: 7.2032

>AT256740 WP_279440727.1 NZ_CP103822:2139875-2140183 [Actinobacillus equuli subsp. haemolyticus]
MGRLFDDLMEGAEALEQYLQGKITLRTTVLEKPEPIELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QAVLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References