Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 2021180..2021834 Replicon chromosome
Accession NZ_CP103821
Organism Actinobacillus equuli subsp. equuli strain 3750

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR76_RS09300 Protein ID WP_278226473.1
Coordinates 2021180..2021542 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR76_RS09305 Protein ID WP_275218140.1
Coordinates 2021526..2021834 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR76_RS09285 (NYR76_09285) 2016751..2017467 + 717 WP_005605560.1 amino acid ABC transporter permease -
NYR76_RS09290 (NYR76_09290) 2017489..2018238 + 750 WP_005621022.1 amino acid ABC transporter ATP-binding protein -
NYR76_RS09295 (NYR76_09295) 2018404..2020998 + 2595 WP_279478221.1 DNA mismatch repair protein MutS -
NYR76_RS09300 (NYR76_09300) 2021180..2021542 + 363 WP_278226473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR76_RS09305 (NYR76_09305) 2021526..2021834 + 309 WP_275218140.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR76_RS09310 (NYR76_09310) 2021974..2022288 + 315 WP_005619625.1 ribosome silencing factor -
NYR76_RS09315 (NYR76_09315) 2022311..2022778 + 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR76_RS09320 (NYR76_09320) 2022861..2024831 + 1971 WP_279478222.1 penicillin-binding protein 2 -
NYR76_RS09325 (NYR76_09325) 2024824..2025948 + 1125 WP_039198374.1 rod shape-determining protein RodA -
NYR76_RS09330 (NYR76_09330) 2026123..2026689 + 567 WP_039198375.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14067.13 Da        Isoelectric Point: 10.1215

>T256738 WP_278226473.1 NZ_CP103821:2021180-2021542 [Actinobacillus equuli subsp. equuli]
VKLVFVELPPFERYRQKHLSDEEYRHFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11628.49 Da        Isoelectric Point: 8.5450

>AT256738 WP_275218140.1 NZ_CP103821:2021526-2021834 [Actinobacillus equuli subsp. equuli]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References