256736

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1939036..1939690 Replicon chromosome
Accession NZ_CP103820
Organism Actinobacillus equuli subsp. haemolyticus strain 3820

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR75_RS09030 Protein ID WP_278226473.1
Coordinates 1939036..1939398 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR75_RS09035 Protein ID WP_279453291.1
Coordinates 1939382..1939690 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR75_RS09015 (NYR75_09020) 1934607..1935323 + 717 WP_005608982.1 amino acid ABC transporter permease -
NYR75_RS09020 (NYR75_09025) 1935345..1936094 + 750 WP_279471675.1 amino acid ABC transporter ATP-binding protein -
NYR75_RS09025 (NYR75_09030) 1936260..1938854 + 2595 WP_279471676.1 DNA mismatch repair protein MutS -
NYR75_RS09030 (NYR75_09035) 1939036..1939398 + 363 WP_278226473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR75_RS09035 (NYR75_09040) 1939382..1939690 + 309 WP_279453291.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR75_RS09040 (NYR75_09045) 1939830..1940144 + 315 WP_005619625.1 ribosome silencing factor -
NYR75_RS09045 (NYR75_09050) 1940167..1940634 + 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR75_RS09050 (NYR75_09055) 1940717..1942687 + 1971 WP_279471677.1 penicillin-binding protein 2 -
NYR75_RS09055 (NYR75_09060) 1942680..1943804 + 1125 WP_279471678.1 rod shape-determining protein RodA -
NYR75_RS09060 (NYR75_09065) 1943979..1944545 + 567 WP_039198375.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14067.13 Da        Isoelectric Point: 10.1215

>T256736 WP_278226473.1 NZ_CP103820:1939036-1939398 [Actinobacillus equuli subsp. haemolyticus]
VKLVFVELPPFERYRQKHLSDEEYRHFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.52 Da        Isoelectric Point: 8.5450

>AT256736 WP_279453291.1 NZ_CP103820:1939382-1939690 [Actinobacillus equuli subsp. haemolyticus]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QAVLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References