256732

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1539272..1540620 Replicon chromosome
Accession NZ_CP103819
Organism Actinobacillus equuli subsp. haemolyticus strain 3873

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag NYR74_RS07095 Protein ID WP_279437033.1
Coordinates 1539589..1540620 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag NYR74_RS07090 Protein ID WP_279444229.1
Coordinates 1539272..1539589 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR74_RS07055 (NYR74_07055) 1534417..1535571 - 1155 WP_279453331.1 DNA-processing protein DprA -
NYR74_RS07060 (NYR74_07060) 1535756..1536268 + 513 WP_039195517.1 peptide deformylase -
NYR74_RS07065 (NYR74_07065) 1536408..1537334 + 927 WP_015674211.1 ADP-glyceromanno-heptose 6-epimerase -
NYR74_RS07070 (NYR74_07070) 1537493..1537987 + 495 WP_279453330.1 hemerythrin domain-containing protein -
NYR74_RS07075 (NYR74_07075) 1538066..1538395 - 330 WP_039198285.1 SMR family transporter -
NYR74_RS07080 (NYR74_07080) 1538483..1538773 - 291 WP_005602339.1 YfcZ/YiiS family protein -
NYR74_RS07085 (NYR74_07085) 1538976..1539284 + 309 WP_279437035.1 helix-turn-helix transcriptional regulator -
NYR74_RS07090 (NYR74_07090) 1539272..1539589 + 318 WP_279444229.1 HipA N-terminal domain-containing protein Antitoxin
NYR74_RS07095 (NYR74_07095) 1539589..1540620 + 1032 WP_279437033.1 HipA domain-containing protein Toxin
NYR74_RS07100 (NYR74_07100) 1540666..1541298 - 633 WP_279453329.1 tellurite resistance TerB family protein -
NYR74_RS07105 (NYR74_07105) 1541465..1541749 - 285 WP_279453328.1 putative quinol monooxygenase -
NYR74_RS07110 (NYR74_07110) 1541771..1542583 - 813 WP_039199081.1 urease accessory protein UreD -
NYR74_RS07115 (NYR74_07115) 1542768..1543403 - 636 WP_005613192.1 urease accessory protein UreG -
NYR74_RS07120 (NYR74_07120) 1543424..1544107 - 684 WP_164997545.1 urease accessory protein UreF -
NYR74_RS07125 (NYR74_07125) 1544119..1544682 - 564 WP_279440749.1 urease accessory protein UreE -
NYR74_RS07130 (NYR74_07130) 1544755..1545372 - 618 WP_279453327.1 glutathione S-transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39591.22 Da        Isoelectric Point: 6.3975

>T256732 WP_279437033.1 NZ_CP103819:1539589-1540620 [Actinobacillus equuli subsp. haemolyticus]
MQNCRVLLTQLTDTEQKSGYSQKGLYYLTGQSDFIPVLPFNRQDFSTLEPRKQQGMSISGYQPKLQLVIHEKQFQSIAQQ
GNYILKPSPEDYPFLAENEHATMQLMAKLGFVVPENGLIPFQSVSEQMEYAFVIKRFDRTNDNKSIHQEQLDGAMNVTEK
YGKTGSDNEQYISYEQAVKFILQHTENNLAQQQELFRRIVYAYLLGNNDLHLRNFSLVYSKTGEANLAPVYDYVSVVPYK
AIFEGTILALPLLVKEEGNKELAHGFTTKYGEYIGQDFIEFGENIGLNRKVILKKLLPQILKEKTIVESVYQRSFMPLEH
QALVLKNYYRRLQLLQILDEPSL

Download         Length: 1032 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12299.12 Da        Isoelectric Point: 5.5957

>AT256732 WP_279444229.1 NZ_CP103819:1539272-1539589 [Actinobacillus equuli subsp. haemolyticus]
MRSIKRSAKVFLYDEPVGYLYQDDMGFHFSYFKDYIGMPLSLSLPVVQQHFHSEQLFPYFASLIPEGWLKAKYNVLQKID
EQDQFGLLLNNGENMLGAITIKREE

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References