256728

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2051570..2052918 Replicon chromosome
Accession NZ_CP103818
Organism Actinobacillus equuli subsp. haemolyticus strain 3874

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag NYR73_RS09575 Protein ID WP_279437033.1
Coordinates 2051570..2052601 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag NYR73_RS09580 Protein ID WP_279444229.1
Coordinates 2052601..2052918 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR73_RS09540 (NYR73_09550) 2046818..2047435 + 618 WP_279453327.1 glutathione S-transferase -
NYR73_RS09545 (NYR73_09555) 2047508..2048071 + 564 WP_279440749.1 urease accessory protein UreE -
NYR73_RS09550 (NYR73_09560) 2048083..2048766 + 684 WP_164997545.1 urease accessory protein UreF -
NYR73_RS09555 (NYR73_09565) 2048787..2049422 + 636 WP_005613192.1 urease accessory protein UreG -
NYR73_RS09560 (NYR73_09570) 2049607..2050419 + 813 WP_039199081.1 urease accessory protein UreD -
NYR73_RS09565 (NYR73_09575) 2050441..2050725 + 285 WP_279453328.1 putative quinol monooxygenase -
NYR73_RS09570 (NYR73_09580) 2050892..2051524 + 633 WP_279453329.1 tellurite resistance TerB family protein -
NYR73_RS09575 (NYR73_09585) 2051570..2052601 - 1032 WP_279437033.1 HipA domain-containing protein Toxin
NYR73_RS09580 (NYR73_09590) 2052601..2052918 - 318 WP_279444229.1 HipA N-terminal domain-containing protein Antitoxin
NYR73_RS09585 (NYR73_09595) 2052906..2053214 - 309 WP_279437035.1 helix-turn-helix transcriptional regulator -
NYR73_RS09590 (NYR73_09600) 2053417..2053707 + 291 WP_005602339.1 YfcZ/YiiS family protein -
NYR73_RS09595 (NYR73_09605) 2053795..2054124 + 330 WP_039198285.1 SMR family transporter -
NYR73_RS09600 (NYR73_09610) 2054203..2054697 - 495 WP_279453330.1 hemerythrin domain-containing protein -
NYR73_RS09605 (NYR73_09615) 2054856..2055782 - 927 WP_015674211.1 ADP-glyceromanno-heptose 6-epimerase -
NYR73_RS09610 (NYR73_09620) 2055922..2056434 - 513 WP_039195517.1 peptide deformylase -
NYR73_RS09615 (NYR73_09625) 2056619..2057773 + 1155 WP_279453331.1 DNA-processing protein DprA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39591.22 Da        Isoelectric Point: 6.3975

>T256728 WP_279437033.1 NZ_CP103818:c2052601-2051570 [Actinobacillus equuli subsp. haemolyticus]
MQNCRVLLTQLTDTEQKSGYSQKGLYYLTGQSDFIPVLPFNRQDFSTLEPRKQQGMSISGYQPKLQLVIHEKQFQSIAQQ
GNYILKPSPEDYPFLAENEHATMQLMAKLGFVVPENGLIPFQSVSEQMEYAFVIKRFDRTNDNKSIHQEQLDGAMNVTEK
YGKTGSDNEQYISYEQAVKFILQHTENNLAQQQELFRRIVYAYLLGNNDLHLRNFSLVYSKTGEANLAPVYDYVSVVPYK
AIFEGTILALPLLVKEEGNKELAHGFTTKYGEYIGQDFIEFGENIGLNRKVILKKLLPQILKEKTIVESVYQRSFMPLEH
QALVLKNYYRRLQLLQILDEPSL

Download         Length: 1032 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12299.12 Da        Isoelectric Point: 5.5957

>AT256728 WP_279444229.1 NZ_CP103818:c2052918-2052601 [Actinobacillus equuli subsp. haemolyticus]
MRSIKRSAKVFLYDEPVGYLYQDDMGFHFSYFKDYIGMPLSLSLPVVQQHFHSEQLFPYFASLIPEGWLKAKYNVLQKID
EQDQFGLLLNNGENMLGAITIKREE

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References