Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1990273..1990927 Replicon chromosome
Accession NZ_CP103818
Organism Actinobacillus equuli subsp. haemolyticus strain 3874

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR73_RS09230 Protein ID WP_278226473.1
Coordinates 1990273..1990635 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR73_RS09235 Protein ID WP_279453291.1
Coordinates 1990619..1990927 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR73_RS09215 (NYR73_09225) 1985843..1986559 + 717 WP_005605560.1 amino acid ABC transporter permease -
NYR73_RS09220 (NYR73_09230) 1986581..1987330 + 750 WP_279453289.1 amino acid ABC transporter ATP-binding protein -
NYR73_RS09225 (NYR73_09235) 1987497..1990091 + 2595 WP_279453290.1 DNA mismatch repair protein MutS -
NYR73_RS09230 (NYR73_09240) 1990273..1990635 + 363 WP_278226473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR73_RS09235 (NYR73_09245) 1990619..1990927 + 309 WP_279453291.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR73_RS09240 (NYR73_09250) 1991067..1991381 + 315 WP_279453292.1 ribosome silencing factor -
NYR73_RS09245 (NYR73_09255) 1991404..1991871 + 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR73_RS09250 (NYR73_09260) 1991954..1993924 + 1971 WP_279453293.1 penicillin-binding protein 2 -
NYR73_RS09255 (NYR73_09265) 1993917..1995041 + 1125 WP_279453294.1 rod shape-determining protein RodA -
NYR73_RS09260 (NYR73_09270) 1995216..1995782 + 567 WP_039198375.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14067.13 Da        Isoelectric Point: 10.1215

>T256727 WP_278226473.1 NZ_CP103818:1990273-1990635 [Actinobacillus equuli subsp. haemolyticus]
VKLVFVELPPFERYRQKHLSDEEYRHFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.52 Da        Isoelectric Point: 8.5450

>AT256727 WP_279453291.1 NZ_CP103818:1990619-1990927 [Actinobacillus equuli subsp. haemolyticus]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QAVLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References