256719

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2050240..2051588 Replicon chromosome
Accession NZ_CP103815
Organism Actinobacillus equuli subsp. haemolyticus strain 4038

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag NYR69_RS09595 Protein ID WP_279437033.1
Coordinates 2050240..2051271 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag NYR69_RS09600 Protein ID WP_279437034.1
Coordinates 2051271..2051588 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR69_RS09560 (NYR69_09565) 2045488..2046105 + 618 WP_039198291.1 glutathione S-transferase -
NYR69_RS09565 (NYR69_09570) 2046178..2046741 + 564 WP_279438414.1 urease accessory protein UreE -
NYR69_RS09570 (NYR69_09575) 2046753..2047436 + 684 WP_279439193.1 urease accessory protein UreF -
NYR69_RS09575 (NYR69_09580) 2047457..2048092 + 636 WP_009874590.1 urease accessory protein UreG -
NYR69_RS09580 (NYR69_09585) 2048277..2049089 + 813 WP_039199081.1 urease accessory protein UreD -
NYR69_RS09585 (NYR69_09590) 2049111..2049395 + 285 WP_279438415.1 putative quinol monooxygenase -
NYR69_RS09590 (NYR69_09595) 2049562..2050194 + 633 WP_279438416.1 DUF533 domain-containing protein -
NYR69_RS09595 (NYR69_09600) 2050240..2051271 - 1032 WP_279437033.1 HipA domain-containing protein Toxin
NYR69_RS09600 (NYR69_09605) 2051271..2051588 - 318 WP_279437034.1 HipA N-terminal domain-containing protein Antitoxin
NYR69_RS09605 (NYR69_09610) 2051576..2051884 - 309 WP_279437035.1 helix-turn-helix transcriptional regulator -
NYR69_RS09610 (NYR69_09615) 2052087..2052377 + 291 WP_005602339.1 YfcZ/YiiS family protein -
NYR69_RS09615 (NYR69_09620) 2052465..2052794 + 330 WP_039198285.1 SMR family transporter -
NYR69_RS09620 (NYR69_09625) 2052873..2053367 - 495 WP_279438417.1 hemerythrin domain-containing protein -
NYR69_RS09625 (NYR69_09630) 2053526..2054452 - 927 WP_015674211.1 ADP-glyceromanno-heptose 6-epimerase -
NYR69_RS09630 (NYR69_09635) 2054592..2055104 - 513 WP_039195517.1 peptide deformylase -
NYR69_RS09635 (NYR69_09640) 2055289..2056443 + 1155 WP_279438418.1 DNA-processing protein DprA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39591.22 Da        Isoelectric Point: 6.3975

>T256719 WP_279437033.1 NZ_CP103815:c2051271-2050240 [Actinobacillus equuli subsp. haemolyticus]
MQNCRVLLTQLTDTEQKSGYSQKGLYYLTGQSDFIPVLPFNRQDFSTLEPRKQQGMSISGYQPKLQLVIHEKQFQSIAQQ
GNYILKPSPEDYPFLAENEHATMQLMAKLGFVVPENGLIPFQSVSEQMEYAFVIKRFDRTNDNKSIHQEQLDGAMNVTEK
YGKTGSDNEQYISYEQAVKFILQHTENNLAQQQELFRRIVYAYLLGNNDLHLRNFSLVYSKTGEANLAPVYDYVSVVPYK
AIFEGTILALPLLVKEEGNKELAHGFTTKYGEYIGQDFIEFGENIGLNRKVILKKLLPQILKEKTIVESVYQRSFMPLEH
QALVLKNYYRRLQLLQILDEPSL

Download         Length: 1032 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12291.10 Da        Isoelectric Point: 4.8047

>AT256719 WP_279437034.1 NZ_CP103815:c2051588-2051271 [Actinobacillus equuli subsp. haemolyticus]
MRSIKRSAKVFLYDEPVGYLYQDEMGFHFSYFKDYIGMPLSLSLPVVQQDFHSEQLFPYFASLIPEGWLKAKYNVLQKID
EQDQFGLLLNNGENMLGAITIKREE

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References