256718

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1995170..1995824 Replicon chromosome
Accession NZ_CP103815
Organism Actinobacillus equuli subsp. haemolyticus strain 4038

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR69_RS09300 Protein ID WP_279438389.1
Coordinates 1995170..1995532 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR69_RS09305 Protein ID WP_275218140.1
Coordinates 1995516..1995824 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR69_RS09285 (NYR69_09290) 1990741..1991457 + 717 WP_005605560.1 amino acid ABC transporter permease -
NYR69_RS09290 (NYR69_09295) 1991479..1992228 + 750 WP_015674150.1 amino acid ABC transporter ATP-binding protein -
NYR69_RS09295 (NYR69_09300) 1992394..1994988 + 2595 WP_279438388.1 DNA mismatch repair protein MutS -
NYR69_RS09300 (NYR69_09305) 1995170..1995532 + 363 WP_279438389.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR69_RS09305 (NYR69_09310) 1995516..1995824 + 309 WP_275218140.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR69_RS09310 (NYR69_09315) 1995964..1996278 + 315 WP_005619625.1 ribosome silencing factor -
NYR69_RS09315 (NYR69_09320) 1996301..1996768 + 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR69_RS09320 (NYR69_09325) 1996851..1998821 + 1971 WP_279438390.1 penicillin-binding protein 2 -
NYR69_RS09325 (NYR69_09330) 1998814..1999938 + 1125 WP_039198374.1 rod shape-determining protein RodA -
NYR69_RS09330 (NYR69_09335) 2000113..2000679 + 567 WP_039198375.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14044.10 Da        Isoelectric Point: 10.1214

>T256718 WP_279438389.1 NZ_CP103815:1995170-1995532 [Actinobacillus equuli subsp. haemolyticus]
VKLVFVELPPFERYRQKHLSDEEYRNFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11628.49 Da        Isoelectric Point: 8.5450

>AT256718 WP_275218140.1 NZ_CP103815:1995516-1995824 [Actinobacillus equuli subsp. haemolyticus]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References