Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1204454..1205099 Replicon chromosome
Accession NZ_CP103815
Organism Actinobacillus equuli subsp. haemolyticus strain 4038

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR69_RS05420 Protein ID WP_081578050.1
Coordinates 1204755..1205099 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR69_RS05415 Protein ID WP_279439166.1
Coordinates 1204454..1204750 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR69_RS05390 (NYR69_05395) 1199631..1200635 - 1005 WP_279439163.1 Holliday junction branch migration DNA helicase RuvB -
NYR69_RS05395 (NYR69_05400) 1200654..1201259 - 606 WP_279439164.1 Holliday junction branch migration protein RuvA -
NYR69_RS05400 (NYR69_05405) 1201401..1202168 - 768 WP_014991849.1 spermidine/putrescine ABC transporter permease PotC -
NYR69_RS05405 (NYR69_05410) 1202168..1203034 - 867 WP_279439165.1 spermidine/putrescine ABC transporter permease PotB -
NYR69_RS05410 (NYR69_05415) 1203021..1204136 - 1116 WP_039197327.1 spermidine/putrescine ABC transporter ATP-binding protein PotA -
NYR69_RS05415 (NYR69_05420) 1204454..1204750 - 297 WP_279439166.1 NadS family protein Antitoxin
NYR69_RS05420 (NYR69_05425) 1204755..1205099 - 345 WP_081578050.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR69_RS05425 (NYR69_05430) 1205305..1207323 + 2019 WP_279439167.1 DNA helicase Rep -
NYR69_RS05430 (NYR69_05435) 1207412..1208164 - 753 WP_279439168.1 TatD family hydrolase -
NYR69_RS05435 (NYR69_05440) 1208258..1209409 - 1152 WP_014991856.1 methionine adenosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(50-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13358.38 Da        Isoelectric Point: 7.9875

>T256716 WP_081578050.1 NZ_CP103815:c1205099-1204755 [Actinobacillus equuli subsp. haemolyticus]
MNSDEYLTFVEVGTFEEDRKQLMADDEYQLFQAYLLEHYELGDFIPHTGGCQKIRWRLPENNKGKSAGVRIIYYVRSLTG
RIYLITMYGKSEKVNLNAREKAIMKKIISRLIGE

Download         Length: 345 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.05 Da        Isoelectric Point: 10.4778

>AT256716 WP_279439166.1 NZ_CP103815:c1204750-1204454 [Actinobacillus equuli subsp. haemolyticus]
MEKRLFERLVQGLEEMVAIEKGEVEVPSHRIHVHKIPNTKAIRTQHHLKQAEFAQLLGVSTNLVQSWEIGRRVPNGAARK
LLAIIEQQPNLVPLLQSL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References