Detailed information of TA system TA256716

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1204454..1205099
• Replicon: chromosome
• Accession: NZ_CP103815
• Organism: Actinobacillus equuli subsp. haemolyticus strain 4038

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: NYR69_RS05420
• Protein ID: WP_081578050.1
• Coordinates: 1204755..1205099 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: NYR69_RS05415
• Protein ID: WP_279439166.1
• Coordinates: 1204454..1204750 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
-	1204454..1204750	-	297	-	-	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (50-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-83)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13358.38 Da
• Isoelectric Point: 7.9875

>T256716 WP_081578050.1 NZ_CP103815:c1205099-1204755 [Actinobacillus equuli subsp. haemolyticus]
MNSDEYLTFVEVGTFEEDRKQLMADDEYQLFQAYLLEHYELGDFIPHTGGCQKIRWRLPENNKGKSAGVRIIYYVRSLTG
RIYLITMYGKSEKVNLNAREKAIMKKIISRLIGE

Nucleotide

• Length: 345 bp

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11157.05 Da
• Isoelectric Point: 10.4778

>AT256716 WP_279439166.1 NZ_CP103815:c1204750-1204454 [Actinobacillus equuli subsp. haemolyticus]
MEKRLFERLVQGLEEMVAIEKGEVEVPSHRIHVHKIPNTKAIRTQHHLKQAEFAQLLGVSTNLVQSWEIGRRVPNGAARK
LLAIIEQQPNLVPLLQSL

Nucleotide

• Length: 297 bp