Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2069803..2071151 Replicon chromosome
Accession NZ_CP103814
Organism Actinobacillus equuli subsp. haemolyticus strain 4091

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag NYR68_RS09660 Protein ID WP_279622219.1
Coordinates 2069803..2070834 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag NYR68_RS09665 Protein ID WP_279622220.1
Coordinates 2070834..2071151 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR68_RS09625 (NYR68_09630) 2065035..2065652 + 618 WP_279455884.1 glutathione S-transferase -
NYR68_RS09630 (NYR68_09635) 2065725..2066288 + 564 WP_279440749.1 urease accessory protein UreE -
NYR68_RS09635 (NYR68_09640) 2066300..2066983 + 684 WP_164997545.1 urease accessory protein UreF -
NYR68_RS09640 (NYR68_09645) 2067004..2067639 + 636 WP_005613192.1 urease accessory protein UreG -
NYR68_RS09645 (NYR68_09650) 2067824..2068636 + 813 WP_279622827.1 urease accessory protein UreD -
NYR68_RS09650 (NYR68_09655) 2068658..2068948 + 291 WP_279622218.1 putative quinol monooxygenase -
NYR68_RS09655 (NYR68_09660) 2069125..2069757 + 633 WP_278226403.1 tellurite resistance TerB family protein -
NYR68_RS09660 (NYR68_09665) 2069803..2070834 - 1032 WP_279622219.1 HipA domain-containing protein Toxin
NYR68_RS09665 (NYR68_09670) 2070834..2071151 - 318 WP_279622220.1 HipA N-terminal domain-containing protein Antitoxin
NYR68_RS09670 (NYR68_09675) 2071139..2071447 - 309 WP_279622221.1 helix-turn-helix transcriptional regulator -
NYR68_RS09675 (NYR68_09680) 2071650..2071940 + 291 WP_279622222.1 YfcZ/YiiS family protein -
NYR68_RS09680 (NYR68_09685) 2072028..2072357 + 330 WP_279455885.1 SMR family transporter -
NYR68_RS09685 (NYR68_09690) 2072425..2072919 - 495 WP_279471695.1 hemerythrin domain-containing protein -
NYR68_RS09690 (NYR68_09695) 2073084..2074010 - 927 WP_015674211.1 ADP-glyceromanno-heptose 6-epimerase -
NYR68_RS09695 (NYR68_09700) 2074151..2074663 - 513 WP_039195517.1 peptide deformylase -
NYR68_RS09700 (NYR68_09705) 2074848..2076002 + 1155 WP_279622223.1 DNA-processing protein DprA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(8-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39607.22 Da        Isoelectric Point: 6.6170

>T256714 WP_279622219.1 NZ_CP103814:c2070834-2069803 [Actinobacillus equuli subsp. haemolyticus]
MQNCRVLLTQLTDTEQKSGYSQKGLYYLTGRSDFIPVLPFNRQDFSTLEPRKQQGMSISGYQPKLQLVIHEKQFQSIAQQ
GNYILKPSPEDYPFLAENEHATMQLMAKLGFVVPENGLIPFQSSSEQTEYAFVIKRFDRTNDNKSIHQEQLDGAMNVMEK
YGKTGSDNEQYISYEQAVKFILQHTENNLAQQQELFRRIVYAYLLGNNDLHLRNFSLVYSKTGEANLAPVYDYVSVVPYK
AIFEGTILALPLLVKEEGNKELAHGFTTKYGEYIGQDFIEFGENIGLNRKVILKKLLPQILKEKTIVESVYQRSFMPLEH
QALVLKNYYRRLQLLQILDEPSL

Download         Length: 1032 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12239.02 Da        Isoelectric Point: 6.4796

>AT256714 WP_279622220.1 NZ_CP103814:c2071151-2070834 [Actinobacillus equuli subsp. haemolyticus]
MRNIKRSAQVFLYDEPVGQIYQDDMGFHFSYFKDYVGIPLSLSLPVAQQHFHSEQLFPYFASLIPEGWLKAKYNVLQKID
EQDHFGLLLNNGENMLGAITIKREK

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References