Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 2018764..2019418 Replicon chromosome
Accession NZ_CP103814
Organism Actinobacillus equuli subsp. haemolyticus strain 4091

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR68_RS09380 Protein ID WP_278226473.1
Coordinates 2018764..2019126 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR68_RS09385 Protein ID WP_275218140.1
Coordinates 2019110..2019418 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR68_RS09365 (NYR68_09370) 2014335..2015051 + 717 WP_279622202.1 amino acid ABC transporter permease -
NYR68_RS09370 (NYR68_09375) 2015073..2015822 + 750 WP_015674150.1 amino acid ABC transporter ATP-binding protein -
NYR68_RS09375 (NYR68_09380) 2015988..2018582 + 2595 WP_279622203.1 DNA mismatch repair protein MutS -
NYR68_RS09380 (NYR68_09385) 2018764..2019126 + 363 WP_278226473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR68_RS09385 (NYR68_09390) 2019110..2019418 + 309 WP_275218140.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR68_RS09390 (NYR68_09395) 2019558..2019872 + 315 WP_279622204.1 ribosome silencing factor -
NYR68_RS09395 (NYR68_09400) 2019895..2020362 + 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR68_RS09400 (NYR68_09405) 2020445..2022415 + 1971 WP_039198373.1 penicillin-binding protein 2 -
NYR68_RS09405 (NYR68_09410) 2022408..2023532 + 1125 WP_039198374.1 rod shape-determining protein RodA -
NYR68_RS09410 (NYR68_09415) 2023707..2024276 + 570 WP_279622205.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14067.13 Da        Isoelectric Point: 10.1215

>T256713 WP_278226473.1 NZ_CP103814:2018764-2019126 [Actinobacillus equuli subsp. haemolyticus]
VKLVFVELPPFERYRQKHLSDEEYRHFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11628.49 Da        Isoelectric Point: 8.5450

>AT256713 WP_275218140.1 NZ_CP103814:2019110-2019418 [Actinobacillus equuli subsp. haemolyticus]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References