Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1965707..1966361 Replicon chromosome
Accession NZ_CP103813
Organism Actinobacillus equuli subsp. equuli strain 4130

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR67_RS09000 Protein ID WP_279470773.1
Coordinates 1965707..1966069 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR67_RS09005 Protein ID WP_275218140.1
Coordinates 1966053..1966361 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR67_RS08985 (NYR67_08985) 1961278..1961994 + 717 WP_005608982.1 amino acid ABC transporter permease -
NYR67_RS08990 (NYR67_08990) 1962016..1962765 + 750 WP_015674150.1 amino acid ABC transporter ATP-binding protein -
NYR67_RS08995 (NYR67_08995) 1962931..1965525 + 2595 WP_279470772.1 DNA mismatch repair protein MutS -
NYR67_RS09000 (NYR67_09000) 1965707..1966069 + 363 WP_279470773.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR67_RS09005 (NYR67_09005) 1966053..1966361 + 309 WP_275218140.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR67_RS09010 (NYR67_09010) 1966501..1966815 + 315 WP_005619625.1 ribosome silencing factor -
NYR67_RS09015 (NYR67_09015) 1966838..1967305 + 468 WP_279470774.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR67_RS09020 (NYR67_09020) 1967388..1969358 + 1971 WP_275218139.1 penicillin-binding protein 2 -
NYR67_RS09025 (NYR67_09025) 1969351..1970475 + 1125 WP_039198374.1 rod shape-determining protein RodA -
NYR67_RS09030 (NYR67_09030) 1970650..1971216 + 567 WP_279470775.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14014.08 Da        Isoelectric Point: 9.8143

>T256710 WP_279470773.1 NZ_CP103813:1965707-1966069 [Actinobacillus equuli subsp. equuli]
VKLVFVELPPFERYRQKHLSDEEYRHFQNELLENPNKGDLIQGTNGLCKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11628.49 Da        Isoelectric Point: 8.5450

>AT256710 WP_275218140.1 NZ_CP103813:1966053-1966361 [Actinobacillus equuli subsp. equuli]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References