256708

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2064555..2065903 Replicon chromosome
Accession NZ_CP103812
Organism Actinobacillus equuli subsp. haemolyticus strain 3826

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag NYR84_RS09535 Protein ID WP_279437033.1
Coordinates 2064555..2065586 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag NYR84_RS09540 Protein ID WP_279437034.1
Coordinates 2065586..2065903 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR84_RS09500 (NYR84_09500) 2059803..2060420 + 618 WP_278226412.1 glutathione S-transferase -
NYR84_RS09505 (NYR84_09505) 2060493..2061056 + 564 WP_279469847.1 urease accessory protein UreE -
NYR84_RS09510 (NYR84_09510) 2061068..2061751 + 684 WP_164997545.1 urease accessory protein UreF -
NYR84_RS09515 (NYR84_09515) 2061772..2062407 + 636 WP_005613192.1 urease accessory protein UreG -
NYR84_RS09520 (NYR84_09520) 2062592..2063404 + 813 WP_279440750.1 urease accessory protein UreD -
NYR84_RS09525 (NYR84_09525) 2063426..2063710 + 285 WP_279469848.1 putative quinol monooxygenase -
NYR84_RS09530 (NYR84_09530) 2063877..2064509 + 633 WP_279469849.1 tellurite resistance TerB family protein -
NYR84_RS09535 (NYR84_09535) 2064555..2065586 - 1032 WP_279437033.1 HipA domain-containing protein Toxin
NYR84_RS09540 (NYR84_09540) 2065586..2065903 - 318 WP_279437034.1 HipA N-terminal domain-containing protein Antitoxin
NYR84_RS09545 (NYR84_09545) 2065891..2066199 - 309 WP_279437035.1 helix-turn-helix transcriptional regulator -
NYR84_RS09550 (NYR84_09550) 2066402..2066692 + 291 WP_005602339.1 YfcZ/YiiS family protein -
NYR84_RS09555 (NYR84_09555) 2066780..2067109 + 330 WP_039198285.1 SMR family transporter -
NYR84_RS09560 (NYR84_09560) 2067188..2067682 - 495 WP_279469850.1 hemerythrin domain-containing protein -
NYR84_RS09565 (NYR84_09565) 2067841..2068767 - 927 WP_015674211.1 ADP-glyceromanno-heptose 6-epimerase -
NYR84_RS09570 (NYR84_09570) 2068907..2069419 - 513 WP_039195517.1 peptide deformylase -
NYR84_RS09575 (NYR84_09575) 2069604..2070758 + 1155 WP_279469851.1 DNA-processing protein DprA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39591.22 Da        Isoelectric Point: 6.3975

>T256708 WP_279437033.1 NZ_CP103812:c2065586-2064555 [Actinobacillus equuli subsp. haemolyticus]
MQNCRVLLTQLTDTEQKSGYSQKGLYYLTGQSDFIPVLPFNRQDFSTLEPRKQQGMSISGYQPKLQLVIHEKQFQSIAQQ
GNYILKPSPEDYPFLAENEHATMQLMAKLGFVVPENGLIPFQSVSEQMEYAFVIKRFDRTNDNKSIHQEQLDGAMNVTEK
YGKTGSDNEQYISYEQAVKFILQHTENNLAQQQELFRRIVYAYLLGNNDLHLRNFSLVYSKTGEANLAPVYDYVSVVPYK
AIFEGTILALPLLVKEEGNKELAHGFTTKYGEYIGQDFIEFGENIGLNRKVILKKLLPQILKEKTIVESVYQRSFMPLEH
QALVLKNYYRRLQLLQILDEPSL

Download         Length: 1032 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12291.10 Da        Isoelectric Point: 4.8047

>AT256708 WP_279437034.1 NZ_CP103812:c2065903-2065586 [Actinobacillus equuli subsp. haemolyticus]
MRSIKRSAKVFLYDEPVGYLYQDEMGFHFSYFKDYIGMPLSLSLPVVQQDFHSEQLFPYFASLIPEGWLKAKYNVLQKID
EQDQFGLLLNNGENMLGAITIKREE

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References