Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 2009616..2010270 Replicon chromosome
Accession NZ_CP103812
Organism Actinobacillus equuli subsp. haemolyticus strain 3826

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR84_RS09240 Protein ID WP_278226473.1
Coordinates 2009616..2009978 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR84_RS09245 Protein ID WP_275218140.1
Coordinates 2009962..2010270 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR84_RS09225 (NYR84_09225) 2005187..2005903 + 717 WP_005605560.1 amino acid ABC transporter permease -
NYR84_RS09230 (NYR84_09230) 2005925..2006674 + 750 WP_015674150.1 amino acid ABC transporter ATP-binding protein -
NYR84_RS09235 (NYR84_09235) 2006840..2009434 + 2595 WP_279469834.1 DNA mismatch repair protein MutS -
NYR84_RS09240 (NYR84_09240) 2009616..2009978 + 363 WP_278226473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR84_RS09245 (NYR84_09245) 2009962..2010270 + 309 WP_275218140.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR84_RS09250 (NYR84_09250) 2010410..2010724 + 315 WP_005619625.1 ribosome silencing factor -
NYR84_RS09255 (NYR84_09255) 2010747..2011214 + 468 WP_279469835.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR84_RS09260 (NYR84_09260) 2011297..2013267 + 1971 WP_279469836.1 penicillin-binding protein 2 -
NYR84_RS09265 (NYR84_09265) 2013260..2014384 + 1125 WP_039198374.1 rod shape-determining protein RodA -
NYR84_RS09270 (NYR84_09270) 2014559..2015125 + 567 WP_039198375.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14067.13 Da        Isoelectric Point: 10.1215

>T256707 WP_278226473.1 NZ_CP103812:2009616-2009978 [Actinobacillus equuli subsp. haemolyticus]
VKLVFVELPPFERYRQKHLSDEEYRHFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11628.49 Da        Isoelectric Point: 8.5450

>AT256707 WP_275218140.1 NZ_CP103812:2009962-2010270 [Actinobacillus equuli subsp. haemolyticus]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References