256703

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2063678..2065026 Replicon chromosome
Accession NZ_CP103810
Organism Actinobacillus equuli subsp. haemolyticus strain CCUG19799

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag NYR64_RS09555 Protein ID WP_279437033.1
Coordinates 2063678..2064709 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag NYR64_RS09560 Protein ID WP_279437034.1
Coordinates 2064709..2065026 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR64_RS09520 (NYR64_09520) 2058925..2059542 + 618 WP_279437028.1 glutathione S-transferase -
NYR64_RS09525 (NYR64_09525) 2059615..2060178 + 564 WP_279437029.1 urease accessory protein UreE -
NYR64_RS09530 (NYR64_09530) 2060190..2060873 + 684 WP_164997545.1 urease accessory protein UreF -
NYR64_RS09535 (NYR64_09535) 2060894..2061529 + 636 WP_278226407.1 urease accessory protein UreG -
NYR64_RS09540 (NYR64_09540) 2061715..2062527 + 813 WP_279437030.1 urease accessory protein UreD -
NYR64_RS09545 (NYR64_09545) 2062549..2062833 + 285 WP_279437031.1 putative quinol monooxygenase -
NYR64_RS09550 (NYR64_09550) 2063000..2063632 + 633 WP_279437032.1 tellurite resistance TerB family protein -
NYR64_RS09555 (NYR64_09555) 2063678..2064709 - 1032 WP_279437033.1 HipA domain-containing protein Toxin
NYR64_RS09560 (NYR64_09560) 2064709..2065026 - 318 WP_279437034.1 HipA N-terminal domain-containing protein Antitoxin
NYR64_RS09565 (NYR64_09565) 2065014..2065322 - 309 WP_279437035.1 helix-turn-helix transcriptional regulator -
NYR64_RS09570 (NYR64_09570) 2065525..2065815 + 291 WP_005602339.1 YfcZ/YiiS family protein -
NYR64_RS09575 (NYR64_09575) 2065903..2066232 + 330 WP_039198285.1 SMR family transporter -
NYR64_RS09580 (NYR64_09580) 2066311..2066805 - 495 WP_279437036.1 hemerythrin domain-containing protein -
NYR64_RS09585 (NYR64_09585) 2066964..2067890 - 927 WP_015674211.1 ADP-glyceromanno-heptose 6-epimerase -
NYR64_RS09590 (NYR64_09590) 2068031..2068543 - 513 WP_039195517.1 peptide deformylase -
NYR64_RS09595 (NYR64_09595) 2068728..2069881 + 1154 Protein_1855 DNA-processing protein DprA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39591.22 Da        Isoelectric Point: 6.3975

>T256703 WP_279437033.1 NZ_CP103810:c2064709-2063678 [Actinobacillus equuli subsp. haemolyticus]
MQNCRVLLTQLTDTEQKSGYSQKGLYYLTGQSDFIPVLPFNRQDFSTLEPRKQQGMSISGYQPKLQLVIHEKQFQSIAQQ
GNYILKPSPEDYPFLAENEHATMQLMAKLGFVVPENGLIPFQSVSEQMEYAFVIKRFDRTNDNKSIHQEQLDGAMNVTEK
YGKTGSDNEQYISYEQAVKFILQHTENNLAQQQELFRRIVYAYLLGNNDLHLRNFSLVYSKTGEANLAPVYDYVSVVPYK
AIFEGTILALPLLVKEEGNKELAHGFTTKYGEYIGQDFIEFGENIGLNRKVILKKLLPQILKEKTIVESVYQRSFMPLEH
QALVLKNYYRRLQLLQILDEPSL

Download         Length: 1032 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12291.10 Da        Isoelectric Point: 4.8047

>AT256703 WP_279437034.1 NZ_CP103810:c2065026-2064709 [Actinobacillus equuli subsp. haemolyticus]
MRSIKRSAKVFLYDEPVGYLYQDEMGFHFSYFKDYIGMPLSLSLPVVQQDFHSEQLFPYFASLIPEGWLKAKYNVLQKID
EQDQFGLLLNNGENMLGAITIKREE

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References