Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1819926..1820580 Replicon chromosome
Accession NZ_CP103809
Organism Actinobacillus genomosp.

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR62_RS08335 Protein ID WP_279475317.1
Coordinates 1820218..1820580 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR62_RS08330 Protein ID WP_275218140.1
Coordinates 1819926..1820234 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR62_RS08305 (NYR62_08305) 1815085..1815642 - 558 WP_279457153.1 septal ring lytic transglycosylase RlpA family protein -
NYR62_RS08310 (NYR62_08310) 1815817..1816941 - 1125 WP_279457154.1 rod shape-determining protein RodA -
NYR62_RS08315 (NYR62_08315) 1816934..1818898 - 1965 WP_279475315.1 penicillin-binding protein 2 -
NYR62_RS08320 (NYR62_08320) 1818981..1819448 - 468 WP_279475316.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR62_RS08325 (NYR62_08325) 1819471..1819785 - 315 WP_005619625.1 ribosome silencing factor -
NYR62_RS08330 (NYR62_08330) 1819926..1820234 - 309 WP_275218140.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR62_RS08335 (NYR62_08335) 1820218..1820580 - 363 WP_279475317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR62_RS08340 (NYR62_08340) 1820759..1823353 - 2595 WP_279475318.1 DNA mismatch repair protein MutS -
NYR62_RS08345 (NYR62_08345) 1823519..1824268 - 750 WP_015674150.1 amino acid ABC transporter ATP-binding protein -
NYR62_RS08350 (NYR62_08350) 1824290..1825006 - 717 WP_279475319.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14039.12 Da        Isoelectric Point: 10.0989

>T256698 WP_279475317.1 NZ_CP103809:c1820580-1820218 [Actinobacillus genomosp. 1]
VKLVFVELPPFERYRQKHLSDEEYKHFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11628.49 Da        Isoelectric Point: 8.5450

>AT256698 WP_275218140.1 NZ_CP103809:c1820234-1819926 [Actinobacillus genomosp. 1]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References