Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1874133..1874787 Replicon chromosome
Accession NZ_CP103808
Organism Actinobacillus genomosp.

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR61_RS08730 Protein ID WP_278226473.1
Coordinates 1874425..1874787 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR61_RS08725 Protein ID WP_279453291.1
Coordinates 1874133..1874441 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR61_RS08700 (NYR61_08700) 1869293..1869850 - 558 WP_279457153.1 septal ring lytic transglycosylase RlpA family protein -
NYR61_RS08705 (NYR61_08705) 1870025..1871149 - 1125 WP_279457154.1 rod shape-determining protein RodA -
NYR61_RS08710 (NYR61_08710) 1871142..1873106 - 1965 WP_279468506.1 penicillin-binding protein 2 -
NYR61_RS08715 (NYR61_08715) 1873189..1873656 - 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR61_RS08720 (NYR61_08720) 1873679..1873993 - 315 WP_005619625.1 ribosome silencing factor -
NYR61_RS08725 (NYR61_08725) 1874133..1874441 - 309 WP_279453291.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR61_RS08730 (NYR61_08730) 1874425..1874787 - 363 WP_278226473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR61_RS08735 (NYR61_08735) 1874966..1877560 - 2595 WP_279468507.1 DNA mismatch repair protein MutS -
NYR61_RS08740 (NYR61_08740) 1877819..1878961 + 1143 WP_279468508.1 esterase-like activity of phytase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14067.13 Da        Isoelectric Point: 10.1215

>T256693 WP_278226473.1 NZ_CP103808:c1874787-1874425 [Actinobacillus genomosp. 1]
VKLVFVELPPFERYRQKHLSDEEYRHFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.52 Da        Isoelectric Point: 8.5450

>AT256693 WP_279453291.1 NZ_CP103808:c1874441-1874133 [Actinobacillus genomosp. 1]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QAVLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References