Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1586784..1587341 Replicon chromosome
Accession NZ_CP103807
Organism Actinobacillus genomosp.

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR60_RS07925 Protein ID WP_279466584.1
Coordinates 1586784..1587032 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR60_RS07930 Protein ID WP_279439545.1
Coordinates 1587033..1587341 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR60_RS07910 (NYR60_07910) 1582263..1582979 + 717 WP_279466580.1 amino acid ABC transporter permease -
NYR60_RS07915 (NYR60_07915) 1583001..1583750 + 750 WP_279466581.1 amino acid ABC transporter ATP-binding protein -
NYR60_RS07920 (NYR60_07920) 1583916..1586510 + 2595 WP_279466583.1 DNA mismatch repair protein MutS -
NYR60_RS07925 (NYR60_07925) 1586784..1587032 + 249 WP_279466584.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR60_RS07930 (NYR60_07930) 1587033..1587341 + 309 WP_279439545.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR60_RS07935 (NYR60_07935) 1587481..1587795 + 315 WP_279466585.1 ribosome silencing factor -
NYR60_RS07940 (NYR60_07940) 1587818..1588285 + 468 WP_279466586.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR60_RS07945 (NYR60_07945) 1588368..1590341 + 1974 WP_279466588.1 penicillin-binding protein 2 -
NYR60_RS07950 (NYR60_07950) 1590334..1591458 + 1125 WP_279466589.1 rod shape-determining protein RodA -
NYR60_RS07955 (NYR60_07955) 1591634..1592191 + 558 WP_279466590.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(15-82)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9446.91 Da        Isoelectric Point: 10.7508

>T256689 WP_279466584.1 NZ_CP103807:1586784-1587032 [Actinobacillus genomosp. 2]
MNNPEAGDIVQGINGLRKIRISTQARGKKGGARVIYYYYVRGSQIWLFTGYNKSRKIDLNSMERKAFSKVLEHLKNIADR
EL

Download         Length: 249 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11618.45 Da        Isoelectric Point: 7.2032

>AT256689 WP_279439545.1 NZ_CP103807:1587033-1587341 [Actinobacillus genomosp. 2]
MGRLFDDLMEGAEALEQYLQGKITLRTTVLEKPEPIELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References