256688

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1458119..1459467 Replicon chromosome
Accession NZ_CP103807
Organism Actinobacillus genomosp.

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag NYR60_RS07325 Protein ID WP_279466436.1
Coordinates 1458436..1459467 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag NYR60_RS07320 Protein ID WP_279466435.1
Coordinates 1458119..1458436 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR60_RS07285 (NYR60_07285) 1454247..1454657 + 411 WP_279466427.1 helix-turn-helix transcriptional regulator -
NYR60_RS07290 (NYR60_07290) 1454821..1455315 + 495 WP_279466429.1 hemerythrin domain-containing protein -
NYR60_RS07295 (NYR60_07295) 1455687..1456199 + 513 WP_279466430.1 hypothetical protein -
NYR60_RS07300 (NYR60_07300) 1456190..1456729 + 540 WP_279466431.1 stationary phase growth adaptation protein -
NYR60_RS07305 (NYR60_07305) 1456912..1457241 - 330 WP_279466433.1 SMR family transporter -
NYR60_RS07310 (NYR60_07310) 1457330..1457620 - 291 WP_005602339.1 YfcZ/YiiS family protein -
NYR60_RS07315 (NYR60_07315) 1457823..1458131 + 309 WP_279457169.1 helix-turn-helix transcriptional regulator -
NYR60_RS07320 (NYR60_07320) 1458119..1458436 + 318 WP_279466435.1 HipA N-terminal domain-containing protein Antitoxin
NYR60_RS07325 (NYR60_07325) 1458436..1459467 + 1032 WP_279466436.1 HipA domain-containing protein Toxin
NYR60_RS07330 (NYR60_07330) 1459514..1460146 - 633 WP_279466437.1 tellurite resistance TerB family protein -
NYR60_RS07335 (NYR60_07335) 1460287..1460571 - 285 WP_279466439.1 putative quinol monooxygenase -
NYR60_RS07340 (NYR60_07340) 1460587..1461399 - 813 WP_279466441.1 urease accessory protein UreD -
NYR60_RS07345 (NYR60_07345) 1461566..1462201 - 636 WP_279466442.1 urease accessory protein UreG -
NYR60_RS07350 (NYR60_07350) 1462222..1462905 - 684 WP_279439193.1 urease accessory protein UreF -
NYR60_RS07355 (NYR60_07355) 1462917..1463480 - 564 WP_279466445.1 urease accessory protein UreE -
NYR60_RS07360 (NYR60_07360) 1463488..1464339 - 852 WP_279466446.1 DNA damage-inducible protein D -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-289)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39278.96 Da        Isoelectric Point: 6.3108

>T256688 WP_279466436.1 NZ_CP103807:1458436-1459467 [Actinobacillus genomosp. 2]
MQNCKVLLTPLTDTEQKSGYSQKGLLYLTGQADFIPVLPFNRQDFSTVEPRKQQGMSISGYQPKIQLVIHEKQFQSIAQQ
GTYILKPSPEDYPFLAENEHATMQLMAKLGFIVPENGLIPFQATSEQTEYAFVIKRFDRTNDNKPIHQEQLDGAMSVTEK
YGKIGSDNEQYISYEQAVKFILKHTENNLAQQQELFRRIVYAYLLGNNDLHLRNFSLIYSKTGEAKLAPIYDYVSVVPYK
AIFEGTILALPLLAKEEGNKELAHGFTTQYGEYIGQDFIEFGENIGLNRNVILKKLLPQILKEKAIVESVYQHSFMPLAH
QELVLKNYSRRLQLLQIIDEPSL

Download         Length: 1032 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12357.19 Da        Isoelectric Point: 6.4660

>AT256688 WP_279466435.1 NZ_CP103807:1458119-1458436 [Actinobacillus genomosp. 2]
MRRIKRSAKVFLYDEPVGYLYQDDMGFHFSYFKDYVGIPLSLSLPVTQQHFRSEQLFPYFASLIPEGWLKAKYNVLQKID
EQDQFGLLLNNGENMLGAITIKREE

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References