Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4440273..4440875 Replicon chromosome
Accession NZ_CP103791
Organism Salmonella enterica subsp. enterica serovar Infantis strain MRS17_00712

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NYQ90_RS21370 Protein ID WP_001159630.1
Coordinates 4440564..4440875 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYQ90_RS21365 Protein ID WP_000362050.1
Coordinates 4440273..4440563 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYQ90_RS21350 (4437766) 4437766..4438668 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NYQ90_RS21355 (4438665) 4438665..4439300 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NYQ90_RS21360 (4439297) 4439297..4440226 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NYQ90_RS21365 (4440273) 4440273..4440563 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NYQ90_RS21370 (4440564) 4440564..4440875 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NYQ90_RS21375 (4441093) 4441093..4442022 + 930 WP_021294279.1 alpha/beta hydrolase -
NYQ90_RS21380 (4442108) 4442108..4442419 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NYQ90_RS21385 (4442416) 4442416..4442862 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NYQ90_RS21390 (4442877) 4442877..4443818 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NYQ90_RS21395 (4443863) 4443863..4444300 - 438 WP_023993693.1 D-aminoacyl-tRNA deacylase -
NYQ90_RS21400 (4444297) 4444297..4445169 - 873 WP_000921423.1 virulence factor BrkB family protein -
NYQ90_RS21405 (4445163) 4445163..4445762 - 600 WP_000965698.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T256679 WP_001159630.1 NZ_CP103791:c4440875-4440564 [Salmonella enterica subsp. enterica serovar Infantis]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT256679 WP_000362050.1 NZ_CP103791:c4440563-4440273 [Salmonella enterica subsp. enterica serovar Infantis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References