Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4913382..4913984 Replicon chromosome
Accession NZ_CP103771
Organism Salmonella enterica strain S1905

Toxin (Protein)


Gene name higB Uniprot ID A0A603E470
Locus tag NYS49_RS23880 Protein ID WP_023138876.1
Coordinates 4913382..4913693 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYS49_RS23885 Protein ID WP_000362050.1
Coordinates 4913694..4913984 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYS49_RS23855 (4909339) 4909339..4909938 + 600 WP_000965695.1 glucose-1-phosphatase -
NYS49_RS23860 (4909932) 4909932..4910804 + 873 WP_000921423.1 virulence factor BrkB family protein -
NYS49_RS23865 (4910801) 4910801..4911238 + 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
NYS49_RS23870 (4911283) 4911283..4912224 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NYS49_RS23875 (4912250) 4912250..4913164 - 915 WP_023138875.1 alpha/beta hydrolase -
NYS49_RS23880 (4913382) 4913382..4913693 + 312 WP_023138876.1 hypothetical protein Toxin
NYS49_RS23885 (4913694) 4913694..4913984 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NYS49_RS23890 (4914031) 4914031..4914960 - 930 WP_023138877.1 formate dehydrogenase accessory protein FdhE -
NYS49_RS23895 (4914957) 4914957..4915592 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NYS49_RS23900 (4915589) 4915589..4916491 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12356.30 Da        Isoelectric Point: 9.4460

>T256634 WP_023138876.1 NZ_CP103771:4913382-4913693 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT256634 WP_000362050.1 NZ_CP103771:4913694-4913984 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A603E470

Antitoxin

Source ID Structure

References