Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2590328..2591055 Replicon chromosome
Accession NZ_CP103771
Organism Salmonella enterica strain S1905

Toxin (Protein)


Gene name higB Uniprot ID A0A8E5IJ81
Locus tag NYS49_RS12545 Protein ID WP_000558157.1
Coordinates 2590328..2590639 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYS49_RS12550 Protein ID WP_000561389.1
Coordinates 2590636..2591055 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYS49_RS12505 (2585372) 2585372..2585767 + 396 WP_000422887.1 DUF1398 domain-containing protein -
NYS49_RS12510 (2586096) 2586096..2586572 + 477 WP_023138823.1 hypothetical protein -
NYS49_RS12515 (2586724) 2586724..2586876 + 153 WP_157794946.1 hypothetical protein -
NYS49_RS12520 (2586988) 2586988..2587446 - 459 WP_001195655.1 hypothetical protein -
NYS49_RS12525 (2587772) 2587772..2588919 + 1148 WP_112324583.1 IS3 family transposase -
NYS49_RS12530 (2588950) 2588950..2589507 - 558 WP_000179886.1 hypothetical protein -
NYS49_RS12535 (2589611) 2589611..2589820 - 210 WP_023137948.1 hypothetical protein -
NYS49_RS12540 (2589850) 2589850..2590149 - 300 WP_000775225.1 hypothetical protein -
NYS49_RS12545 (2590328) 2590328..2590639 + 312 WP_000558157.1 type II toxin-antitoxin system HigB family toxin Toxin
NYS49_RS12550 (2590636) 2590636..2591055 + 420 WP_000561389.1 helix-turn-helix domain-containing protein Antitoxin
NYS49_RS12555 (2591308) 2591308..2591960 + 653 Protein_2451 glycosyltransferase -
NYS49_RS12560 (2592196) 2592196..2592615 - 420 WP_023137951.1 GNAT family N-acetyltransferase -
NYS49_RS12565 (2592985) 2592985..2593254 + 270 WP_077908593.1 hypothetical protein -
NYS49_RS12570 (2593420) 2593420..2593560 + 141 WP_001576018.1 hypothetical protein -
NYS49_RS12575 (2593706) 2593706..2594247 - 542 Protein_2455 transposase -
NYS49_RS12580 (2594267) 2594267..2594359 - 93 WP_231923105.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2587772..2594044 6272
- inside Genomic island - sopE2 2583966..2594382 10416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12425.26 Da        Isoelectric Point: 10.1376

>T256625 WP_000558157.1 NZ_CP103771:2590328-2590639 [Salmonella enterica]
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRKVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15301.49 Da        Isoelectric Point: 4.6286

>AT256625 WP_000561389.1 NZ_CP103771:2590636-2591055 [Salmonella enterica]
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References